Статья

Multiparametric Prognostic Scores in Chronic Heart Failure with Reduced Ejection Fraction: A Long-Term Comparison

Piergiuseppe AgostoniCardiovascular Section, Department of Clinical Sciences and Community Health, University of Milan , Milan ,Stefania PaolilloSDN IRCCS , Naples ,Massimo MapelliCentro Cardiologico Monzino, IRCCS , Milan ,Piero GentileCardiovascular Department, Ospedali Riuniti and University of Trieste , Trieste ,Elisabetta SalvioniCentro Cardiologico Monzino, IRCCS , Milan ,Fabrizio VegliaCentro Cardiologico Monzino, IRCCS , Milan ,Alice BonomiCentro Cardiologico Monzino, IRCCS , Milan ,Ugo CorràDivision of Cardiac Rehabilitation, Salvatore Maugeri Foundation, IRCCS, Scientific Institute of Veruno, Veruno Rocco LagioiaDivision of Cardiology, Salvatore Maugeri Foundation, IRCCS, Scientific Institute of Cassano Murge , Bari ,Giuseppe LimongelliCardiology SUN, Monaldi Hospital (Azienda dei Colli), Second University of Naples , Naples ,Gianfranco SinagraCardiovascular Department, Ospedali Riuniti and University of Trieste , Trieste ,Gaia CattadoriCardiac Rehabilitation Unit, Multimedica IRCCS , Milan ,Angela Beatrice ScardoviCardiology Division, Santo Spirito Hospital , Rome ,Marco MetraCardiology, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia , Brescia ,Valentina CarubelliCardiology, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia , Brescia ,Domenico ScrutinioDivision of Cardiology, Salvatore Maugeri Foundation, IRCCS, Scientific Institute of Cassano Murge , Bari ,Rosa RaimondoSalvatore Maugeri Foundation, IRCCS, Scientific Institute of Tradate, Tradate Michele EmdinGabriele Monasterio Foundation, CNR-Regione Toscana , Pisa ,Massimo PiepoliHeart Failure Unit, Cardiac Department, Guglielmo da Saliceto Hospital , Piacenza ,Damiano MagrìDepartment of Clinical and Molecular Medicine, Sant'Andrea Hospital, Sapienza University of Rome , Rome ,Gianfranco ParatiDepartment of Cardiovascular, Neural and Metabolic Sciences, San Luca Hospital, Istituto Auxologico Italiano , Milan ,Sergio CaravitaDepartment of Cardiovascular, Neural and Metabolic Sciences, San Luca Hospital, Istituto Auxologico Italiano , Milan ,Federica ReCardiology Division, Cardiac Arrhythmia Center and Cardiomyopathies Unit, San Camillo-Forlanini Hospital , Rome ,Mariantonietta CicoiraSection of Cardiology, Department of Medicine, University of Verona , Verona ,Chiara MinàDepartment for the Treatment and Study of Cardiothoracic Diseases and Cardiothoracic Transplantation, IRCCS – ISMETT , Palermo ,Michele CorrealeDepartment of Cardiology, University of Foggia , Foggia ,Maria FrigerioDe Gasperis Cardiocenter, Niguarda Ca' Granda Hospital , Milan ,Maurizio BussottiCardiac Rehabilitation Unit, Salvatore Maugeri Foundation, IRCCS, Scientific Institute of Milan , Milan ,Fabrizio OlivaDepartment of Cardiology, S. Chiara Hospital , Trento ,Elisa BattaiaDepartment of Cardiology, S. Chiara Hospital , Trento ,Romualdo BelardinelliCardiac Rehabilitation, Azienda Ospedali Riuniti , Ancona ,Alessandro MezzaniDivision of Cardiac Rehabilitation, Salvatore Maugeri Foundation, IRCCS, Scientific Institute of Veruno, Veruno Luigi Emilio PastormerloGabriele Monasterio Foundation, CNR-Regione Toscana , Pisa ,Marco GuazziCardiology University Department, Heart Failure Unit and Cardiopulmonary Laboratory, IRCCS Policlinico San Donato, San Donato Milanese , Milan ,Roberto BadagliaccaDepartment of Cardiovascular, Respiratory, Nephrology, Anesthesiology and Geriatric Sciences, Sapienza University of Rome , Rome ,Andrea Di LenardaCardiovascular Center, Health Authority n. 1 and University of Trieste , Trieste ,Claudio PassinoGabriele Monasterio Foundation, CNR-Regione Toscana , Pisa ,Susanna SciomerDepartment of Cardiovascular, Respiratory, Nephrology, Anesthesiology and Geriatric Sciences, Sapienza University of Rome , Rome ,Elena ZambonCardiovascular Department, Ospedali Riuniti and University of Trieste , Trieste ,Giuseppe PacileoCardiology SUN, Monaldi Hospital (Azienda dei Colli), Second University of Naples , Naples ,Roberto RicciCardiology Division, Santo Spirito Hospital , Rome ,Anna ApostoloCentro Cardiologico Monzino, IRCCS , Milan ,Pietro PalermoCentro Cardiologico Monzino, IRCCS , Milan ,Mauro ContiniCentro Cardiologico Monzino, IRCCS , Milan ,Francesco ClemenzaSection of Cardiology, Department of Medicine, University of Verona , Verona ,Giovanni MarcheseDe Gasperis Cardiocenter, Niguarda Ca' Granda Hospital , Milan ,Paola GargiuloSDN IRCCS , Naples ,Simone BinnoHeart Failure Unit, Cardiac Department, Guglielmo da Saliceto Hospital , Piacenza ,Carlo LombardiCardiology, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia , Brescia ,Andrea PassantinoDivision of Cardiology, Salvatore Maugeri Foundation, IRCCS, Scientific Institute of Cassano Murge , Bari ,Pasquale Perrone FilardiDepartment of Advanced Biomedical Sciences, Federico II University of Naples , Naples ,

2017en

ABI

Аннотация

AIMS: Risk stratification in heart failure (HF) is crucial for clinical and therapeutic management. A multiparametric approach is the best method to stratify prognosis. In 2012, the Metabolic Exercise test data combined with Cardiac and Kidney Indexes (MECKI) score was proposed to assess the risk of cardiovascular mortality and urgent heart transplantation. The aim of the present study was to compare the prognostic accuracy of MECKI score to that of HF Survival Score (HFSS) and Seattle HF Model (SHFM) in a large, multicentre cohort of HF patients with reduced ejection fraction. METHODS AND RESULTS: We collected data on 6112 HF patients and compared the prognostic accuracy of MECKI score, HFSS, and SHFM at 2- and 4-year follow-up for the combined endpoint of cardiovascular death, urgent cardiac transplantation, or ventricular assist device implantation. Patients were followed up for a median of 3.67 years, and 931 cardiovascular deaths, 160 urgent heart transplantations, and 12 ventricular assist device implantations were recorded. At 2-year follow-up, the prognostic accuracy of MECKI score was significantly superior [area under the curve (AUC) 0.781] to that of SHFM (AUC 0.739) and HFSS (AUC 0.723), and this relationship was also confirmed at 4 years (AUC 0.764, 0.725, and 0.720, respectively). CONCLUSION: In this cohort, the prognostic accuracy of the MECKI score was superior to that of HFSS and SHFM at 2- and 4-year follow-up in HF patients in stable clinical condition. The MECKI score may be useful to improve resource allocation and patient outcome, but prospective evaluation is needed.

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Идентификаторы

DOI: 10.1002/ejhf.989

Цитирования и источники

Цитирований: 2Использованных источников: 0

Показатели — AkademScholar