Isolation, Structure Elucidation, and Absolute Configuration of 26-Deoxyactein from <i>Cimicifuga </i><i>r</i><i>acemosa</i> and Clarification of Nomenclature Associated with 27-Deoxyactein
Shao‐Nong ChenProgram for Collaborative Research in the Pharmaceutical Sciences (PCRPS, M/C 877), Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 S. Wood Street, Chicago, Illinois 60612, Center for Pharmaceutical Biotechnology (M/C 870), University of Illinois at Chicago, Chicago, Illinois 60612, and UIC/NIH Center for Botanical Dietary Supplements Research, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612Wenkui LiProgram for Collaborative Research in the Pharmaceutical Sciences (PCRPS, M/C 877), Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 S. Wood Street, Chicago, Illinois 60612, Center for Pharmaceutical Biotechnology (M/C 870), University of Illinois at Chicago, Chicago, Illinois 60612, and UIC/NIH Center for Botanical Dietary Supplements Research, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612Daniel S. FabricantProgram for Collaborative Research in the Pharmaceutical Sciences (PCRPS, M/C 877), Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 S. Wood Street, Chicago, Illinois 60612, Center for Pharmaceutical Biotechnology (M/C 870), University of Illinois at Chicago, Chicago, Illinois 60612, and UIC/NIH Center for Botanical Dietary Supplements Research, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612Bernard D. SantarsieroProgram for Collaborative Research in the Pharmaceutical Sciences (PCRPS, M/C 877), Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 S. Wood Street, Chicago, Illinois 60612, Center for Pharmaceutical Biotechnology (M/C 870), University of Illinois at Chicago, Chicago, Illinois 60612, and UIC/NIH Center for Botanical Dietary Supplements Research, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612Andrew D. MesecarProgram for Collaborative Research in the Pharmaceutical Sciences (PCRPS, M/C 877), Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 S. Wood Street, Chicago, Illinois 60612, Center for Pharmaceutical Biotechnology (M/C 870), University of Illinois at Chicago, Chicago, Illinois 60612, and UIC/NIH Center for Botanical Dietary Supplements Research, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612John F. FitzloffProgram for Collaborative Research in the Pharmaceutical Sciences (PCRPS, M/C 877), Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 S. Wood Street, Chicago, Illinois 60612, Center for Pharmaceutical Biotechnology (M/C 870), University of Illinois at Chicago, Chicago, Illinois 60612, and UIC/NIH Center for Botanical Dietary Supplements Research, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612Harry H. S. FongProgram for Collaborative Research in the Pharmaceutical Sciences (PCRPS, M/C 877), Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 S. Wood Street, Chicago, Illinois 60612, Center for Pharmaceutical Biotechnology (M/C 870), University of Illinois at Chicago, Chicago, Illinois 60612, and UIC/NIH Center for Botanical Dietary Supplements Research, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612Norman R. FarnsworthProgram for Collaborative Research in the Pharmaceutical Sciences (PCRPS, M/C 877), Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 S. Wood Street, Chicago, Illinois 60612, Center for Pharmaceutical Biotechnology (M/C 870), University of Illinois at Chicago, Chicago, Illinois 60612, and UIC/NIH Center for Botanical Dietary Supplements Research, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612
2002en
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Аннотация
A new triterpene glycoside, 26-deoxyactein (1), along with two known compounds, 23-epi-26-deoxyactein (2), previously designated as "27-deoxyactein", and actein (3), were isolated from the roots/rhizomes of Cimicifuga racemosa. The structures and absolute stereochemistry of 1 and 2 were established by spectroscopic methods (FABMS, (1)H and (13)C NMR) and single-crystal X-ray data analysis.
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