Effectiveness of Computerized Decision Support Systems Linked to Electronic Health Records: A Systematic Review and Meta-Analysis
Lorenzo MojaLorenzo Moja is with the Department of Biomedical Sciences for Health, University of Milan, and the Unit of Clinical Epidemiology, IRCCS Orthopedic Institute Galeazzi, Milan, Italy. Koren H. Kwag is with the Unit of Clinical Epidemiology, IRCCS Orthopedic Institute Galeazzi, Milan. Theodore Lytras is with the Department of Epidemiological Surveillance and Intervention, Hellenic Centre for Disease Control and Prevention, Athens, Greece, the Centre for Research in Environmental Epidemiology (CREAL),Koren Hyogene KwagLorenzo Moja is with the Department of Biomedical Sciences for Health, University of Milan, and the Unit of Clinical Epidemiology, IRCCS Orthopedic Institute Galeazzi, Milan, Italy. Koren H. Kwag is with the Unit of Clinical Epidemiology, IRCCS Orthopedic Institute Galeazzi, Milan. Theodore Lytras is with the Department of Epidemiological Surveillance and Intervention, Hellenic Centre for Disease Control and Prevention, Athens, Greece, the Centre for Research in Environmental Epidemiology (CREAL),Theodore LytrasLorenzo Moja is with the Department of Biomedical Sciences for Health, University of Milan, and the Unit of Clinical Epidemiology, IRCCS Orthopedic Institute Galeazzi, Milan, Italy. Koren H. Kwag is with the Unit of Clinical Epidemiology, IRCCS Orthopedic Institute Galeazzi, Milan. Theodore Lytras is with the Department of Epidemiological Surveillance and Intervention, Hellenic Centre for Disease Control and Prevention, Athens, Greece, the Centre for Research in Environmental Epidemiology (CREAL),Lorenzo BertizzoloLorenzo Moja is with the Department of Biomedical Sciences for Health, University of Milan, and the Unit of Clinical Epidemiology, IRCCS Orthopedic Institute Galeazzi, Milan, Italy. Koren H. Kwag is with the Unit of Clinical Epidemiology, IRCCS Orthopedic Institute Galeazzi, Milan. Theodore Lytras is with the Department of Epidemiological Surveillance and Intervention, Hellenic Centre for Disease Control and Prevention, Athens, Greece, the Centre for Research in Environmental Epidemiology (CREAL),Linn BrandtLorenzo Moja is with the Department of Biomedical Sciences for Health, University of Milan, and the Unit of Clinical Epidemiology, IRCCS Orthopedic Institute Galeazzi, Milan, Italy. Koren H. Kwag is with the Unit of Clinical Epidemiology, IRCCS Orthopedic Institute Galeazzi, Milan. Theodore Lytras is with the Department of Epidemiological Surveillance and Intervention, Hellenic Centre for Disease Control and Prevention, Athens, Greece, the Centre for Research in Environmental Epidemiology (CREAL),V.L. PecoraroLorenzo Moja is with the Department of Biomedical Sciences for Health, University of Milan, and the Unit of Clinical Epidemiology, IRCCS Orthopedic Institute Galeazzi, Milan, Italy. Koren H. Kwag is with the Unit of Clinical Epidemiology, IRCCS Orthopedic Institute Galeazzi, Milan. Theodore Lytras is with the Department of Epidemiological Surveillance and Intervention, Hellenic Centre for Disease Control and Prevention, Athens, Greece, the Centre for Research in Environmental Epidemiology (CREAL),Giulio RigonLorenzo Moja is with the Department of Biomedical Sciences for Health, University of Milan, and the Unit of Clinical Epidemiology, IRCCS Orthopedic Institute Galeazzi, Milan, Italy. Koren H. Kwag is with the Unit of Clinical Epidemiology, IRCCS Orthopedic Institute Galeazzi, Milan. Theodore Lytras is with the Department of Epidemiological Surveillance and Intervention, Hellenic Centre for Disease Control and Prevention, Athens, Greece, the Centre for Research in Environmental Epidemiology (CREAL),Alberto VaonaLorenzo Moja is with the Department of Biomedical Sciences for Health, University of Milan, and the Unit of Clinical Epidemiology, IRCCS Orthopedic Institute Galeazzi, Milan, Italy. Koren H. Kwag is with the Unit of Clinical Epidemiology, IRCCS Orthopedic Institute Galeazzi, Milan. Theodore Lytras is with the Department of Epidemiological Surveillance and Intervention, Hellenic Centre for Disease Control and Prevention, Athens, Greece, the Centre for Research in Environmental Epidemiology (CREAL),Francesca RuggieroLorenzo Moja is with the Department of Biomedical Sciences for Health, University of Milan, and the Unit of Clinical Epidemiology, IRCCS Orthopedic Institute Galeazzi, Milan, Italy. Koren H. Kwag is with the Unit of Clinical Epidemiology, IRCCS Orthopedic Institute Galeazzi, Milan. Theodore Lytras is with the Department of Epidemiological Surveillance and Intervention, Hellenic Centre for Disease Control and Prevention, Athens, Greece, the Centre for Research in Environmental Epidemiology (CREAL),Massimo MangiaLorenzo Moja is with the Department of Biomedical Sciences for Health, University of Milan, and the Unit of Clinical Epidemiology, IRCCS Orthopedic Institute Galeazzi, Milan, Italy. Koren H. Kwag is with the Unit of Clinical Epidemiology, IRCCS Orthopedic Institute Galeazzi, Milan. Theodore Lytras is with the Department of Epidemiological Surveillance and Intervention, Hellenic Centre for Disease Control and Prevention, Athens, Greece, the Centre for Research in Environmental Epidemiology (CREAL),Alfonso IorioLorenzo Moja is with the Department of Biomedical Sciences for Health, University of Milan, and the Unit of Clinical Epidemiology, IRCCS Orthopedic Institute Galeazzi, Milan, Italy. Koren H. Kwag is with the Unit of Clinical Epidemiology, IRCCS Orthopedic Institute Galeazzi, Milan. Theodore Lytras is with the Department of Epidemiological Surveillance and Intervention, Hellenic Centre for Disease Control and Prevention, Athens, Greece, the Centre for Research in Environmental Epidemiology (CREAL),Ilkka KunnamoLorenzo Moja is with the Department of Biomedical Sciences for Health, University of Milan, and the Unit of Clinical Epidemiology, IRCCS Orthopedic Institute Galeazzi, Milan, Italy. Koren H. Kwag is with the Unit of Clinical Epidemiology, IRCCS Orthopedic Institute Galeazzi, Milan. Theodore Lytras is with the Department of Epidemiological Surveillance and Intervention, Hellenic Centre for Disease Control and Prevention, Athens, Greece, the Centre for Research in Environmental Epidemiology (CREAL),Stefanos BonovasLorenzo Moja is with the Department of Biomedical Sciences for Health, University of Milan, and the Unit of Clinical Epidemiology, IRCCS Orthopedic Institute Galeazzi, Milan, Italy. Koren H. Kwag is with the Unit of Clinical Epidemiology, IRCCS Orthopedic Institute Galeazzi, Milan. Theodore Lytras is with the Department of Epidemiological Surveillance and Intervention, Hellenic Centre for Disease Control and Prevention, Athens, Greece, the Centre for Research in Environmental Epidemiology (CREAL),
2014en
ABI
Аннотация
We systematically reviewed randomized controlled trials (RCTs) assessing the effectiveness of computerized decision support systems (CDSSs) featuring rule- or algorithm-based software integrated with electronic health records (EHRs) and evidence-based knowledge. We searched MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, and Cochrane Database of Abstracts of Reviews of Effects. Information on system design, capabilities, acquisition, implementation context, and effects on mortality, morbidity, and economic outcomes were extracted. Twenty-eight RCTs were included. CDSS use did not affect mortality (16 trials, 37395 patients; 2282 deaths; risk ratio [RR] = 0.96; 95% confidence interval [CI] = 0.85, 1.08; I(2) = 41%). A statistically significant effect was evident in the prevention of morbidity, any disease (9 RCTs; 13868 patients; RR = 0.82; 95% CI = 0.68, 0.99; I(2) = 64%), but selective outcome reporting or publication bias cannot be excluded. We observed differences for costs and health service utilization, although these were often small in magnitude. Across clinical settings, new generation CDSSs integrated with EHRs do not affect mortality and might moderately improve morbidity outcomes.
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