Статья

Clinical presentation, aetiology and outcome of infective endocarditis. Results of the ESC-EORP EURO-ENDO (European infective endocarditis) registry: a prospective cohort study

Gilbert HabibAix Marseille University, IRD, APHM, MEPHI, IHU-Méditerranée Infection , Marseille, FrancePaola Anna ErbaMedical Imaging Center, University Medical Center Groningen , Groningen, The NetherlandsBernard IungBichat Hospital, APHP, DHU Fire, Paris Diderot University , Paris, FranceErwan DonalUniversity of Rennes, CHU Rennes, Inserm , LTSI – UMR 1099, Rennes, FranceBernard CosynsCécile LarocheEURObservational Research Programme (EORP), European Society of Cardiology , Sophia-Antipolis, FranceBogdan A. PopescuDepartment of Cardiology, University of Medicine and Pharmacy “Carol Davila” Euroecolab, Emergency Institute of Cardiovascular Diseases “Prof. Dr C. C. Iliescu”, Bucharest, RomaniaBernard PrendergastDepartment of Cardiology, Guy's and St Thomas' Hospital , London, Great BritainPilar TornosDepartment of Cardiology, Hospital Quiron BarcelonaAnita SadeghpourEchocardiography Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences , Tehran, IranLéopold OliverDepartment of Cardiovascular Medicine, SOS Endocardites Unit, Henri-Mondor University Hospital , AP-HP, Creteil, FranceJolanta-Justina VaškelytėDepartment of Cardiology, Lithuanian University of Health Sciences , Kaunas, LithuaniaRouguiatou SowLuxembourg Hospital Centre , LuxembourgOlivier AxlerCardiology Department, Gaston Bourret Hospital Centre, New Caledonia University , Noumea, New Caledonia, FranceAldo P. MaggioniEURObservational Research Programme, European Society of Cardiology , FrancePatrizio LancellottiANMCO Research Center , Florence, ItalyEURO-ENDO InvestigatorsChris P GaleDepartment of Cardiology, Guy's and St Thomas' Hospital, London, Great BritainB. BeleslinAndrzej BudajGruppo Villa Maria Care and Research, Anthea Hospital, Bari, ItalyOvidiu ChioncelANMCO Research Center, Florence, Italy;Nikolaos DagresDepartment of Cardiology, Heart Valve Clinic, University of Liege Hospital, GIGA Cardiovascular Sciences, CHU Sart Tilman, Liege, Belgium; andNicolas DanchinDepartment of Cardiology, Lithuanian University of Health Sciences, Kaunas, LithuaniaJonathan EmbersonEURObservational Research Programme, European Society of Cardiology, France;David ErlingeEURObservational Research Programme, European Society of Cardiology, FranceMichael GliksonAdam GrayEURObservational Research Programme, European Society of Cardiology, FranceM KayikciogluEURObservational Research Programme, European Society of Cardiology, FranceV K NagyА. О. НедошивинDepartment of Cardiology, Lithuanian University of Health Sciences, Kaunas, LithuaniaA-S PetronioDepartment of Cardiology, Lithuanian University of Health Sciences, Kaunas, LithuaniaJolien W. Roos‐HesselinkGruppo Villa Maria Care and Research, Anthea Hospital, Bari, ItalyLars WallentinLuxembourg Hospital Centre, Luxembourg;Uwe ZeymerAix Marseille University, IRD, APHM, MEPHI, IHU-Méditerranée Infection, Marseille, FranceB CosynsCenter for Cardiovascular Diseases (CHVZ), University Hospital Brussel , Brussels, BelgiumB PrendergastDepartment of Cardiology, Guy's and St Thomas' Hospital , London, Great BritainP. TornosDepartment of Cardiology, Hospital Quiron BarcelonaMaryna AndaralaANMCO Research Center, Florence, ItalyC BerleA Brunel-LebecqANMCO Research Center, Florence, Italy;E FiorucciEURObservational Research Programme (EORP), European Society of Cardiology, Sophia-Antipolis, FranceC LarocheEURObservational Research Programme (EORP), European Society of Cardiology , Sophia-Antipolis, FranceV. MissiamenouGruppo Villa Maria Care and Research, Anthea Hospital, Bari, ItalyClare TaylorNuclear Medicine, Department of Translational Research and New Technology, Medicine University of Pisa and Azienda Ospedaliero Universitaria Pisana, Pisa, ItalyNora Nabila Ali Tatar-ChentirEURObservational Research Programme, European Society of Cardiology, FranceMouaz H. Al‐MallahEURObservational Research Programme, European Society of Cardiology, FranceMeriam Åström AneqEURObservational Research Programme, European Society of Cardiology, France;George AthanassopoulosLuigi P. BadanoLuxembourg Hospital Centre, Luxembourg;S. BenyoussefANMCO Research Center, Florence, Italy;Erick Calderón-ArandaNuno CardimKL ChanB CosynsCenter for Cardiovascular Diseases (CHVZ), University Hospital Brussel , Brussels, BelgiumIsabel CruzANMCO Research Center, Florence, Italy;Thor EdvardsenEURObservational Research Programme, European Society of Cardiology, France;Georg GoliaschCardiology Department, APHM, La Timone Hospital, Boulevard Jean Moulin, Marseille, FranceAndreas HagendorffDepartment of Cardiology, Lithuanian University of Health Sciences, Kaunas, LithuaniaKrasimira HristováBichat Hospital, APHP, DHU Fire, Paris Diderot University, Paris, FranceOtto KampD-H KangLuxembourg Hospital Centre, LuxembourgWilliam KongLuxembourg Hospital Centre, Luxembourg;С.Т. МацкеплишвилиEURObservational Research Programme, European Society of Cardiology, FranceMarwa MeshaalEURObservational Research Programme, European Society of Cardiology, FranceM MirocevicDepartment of Cardiology, Heart Valve Clinic, University of Liege Hospital, GIGA Cardiovascular Sciences, CHU Sart Tilman, Liege, Belgium; andAleksandar NeškovićEURObservational Research Programme, European Society of Cardiology, FranceMichal PazderníkGruppo Villa Maria Care and Research, Anthea Hospital, Bari, ItalyE Plonska-GosciniakDepartment of Cardiology, University of Medicine and Pharmacy "Carol Davila" Euroecolab, Emergency Institute of Cardiovascular Diseases "Prof. Dr C. C. Iliescu", Bucharest, RomaniaB PrendergastDepartment of Cardiology, Guy's and St Thomas' Hospital , London, Great BritainMaha RaissouniGruppo Villa Maria Care and Research, Anthea Hospital, Bari, ItalyRicardo RonderosEchocardiography Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IranL E SadeEchocardiography Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IranAntonia SambolaLuxembourg Hospital Centre, Luxembourg;Shantanu P. SenguptaDepartment of Cardiology, Lithuanian University of Health Sciences, Kaunas, LithuaniaJ Separovic-HanzevackiEURObservational Research Programme, European Society of Cardiology, FranceMasami TakeuchiANMCO Research Center, Florence, Italy;Edwin S. TucayGruppo Villa Maria Care and Research, Anthea Hospital, Bari, ItalyAna Clara Tude RodriguesAndréa VargaDepartment of Cardiology, Lithuanian University of Health Sciences, Kaunas, LithuaniaJ. VaskelyteDepartment of Cardiology, Lithuanian University of Health Sciences , Kaunas, LithuaniaKazufumi YamagataDepartment of Cardiology, Lithuanian University of Health Sciences, Kaunas, LithuaniaK YiangouEchocardiography Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IranH ZakyDepartment of Cardiology, Heart Valve Clinic, University of Liege Hospital, GIGA Cardiovascular Sciences, CHU Sart Tilman, Liege, Belgium; andIsabel GranadaEURObservational Research Programme, European Society of Cardiology, FranceM MahiaLuxembourg Hospital Centre, Luxembourg;S RessiFrancisco NacinovichAna IribarrenANMCO Research Center, Florence, Italy

2019en

ABI

Аннотация

AIMS: The EURO-ENDO registry aimed to study the management and outcomes of patients with infective endocarditis (IE). METHODS AND RESULTS: Prospective cohort of 3116 adult patients (2470 from Europe, 646 from non-ESC countries), admitted to 156 hospitals in 40 countries between January 2016 and March 2018 with a diagnosis of IE based on ESC 2015 diagnostic criteria. Clinical, biological, microbiological, and imaging [echocardiography, computed tomography (CT) scan, 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT)] data were collected. Infective endocarditis was native (NVE) in 1764 (56.6%) patients, prosthetic (PVIE) in 939 (30.1%), and device-related (CDRIE) in 308 (9.9%). Infective endocarditis was community-acquired in 2046 (65.66%) patients. Microorganisms involved were staphylococci in 1085 (44.1%) patients, oral streptococci in 304 (12.3%), enterococci in 390 (15.8%), and Streptococcus gallolyticus in 162 (6.6%). 18F-fluorodeoxyglucose positron emission tomography/computed tomography was performed in 518 (16.6%) patients and presented with cardiac uptake (major criterion) in 222 (42.9%) patients, with a better sensitivity in PVIE (66.8%) than in NVE (28.0%) and CDRIE (16.3%). Embolic events occurred in 20.6% of patients, and were significantly associated with tricuspid or pulmonary IE, presence of a vegetation and Staphylococcus aureus IE. According to ESC guidelines, cardiac surgery was indicated in 2160 (69.3%) patients, but finally performed in only 1596 (73.9%) of them. In-hospital death occurred in 532 (17.1%) patients and was more frequent in PVIE. Independent predictors of mortality were Charlson index, creatinine > 2 mg/dL, congestive heart failure, vegetation length > 10 mm, cerebral complications, abscess, and failure to undertake surgery when indicated. CONCLUSION: Infective endocarditis is still a life-threatening disease with frequent lethal outcome despite profound changes in its clinical, microbiological, imaging, and therapeutic profiles.

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Идентификаторы

DOI: 10.1093/eurheartj/ehz620

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