Central nervous system involvement by severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2)
Alberto Paniz‐MondolfiDepartment of Pathology Molecular and Cell‐Based Medicine, Icahn School of Medicine at Mount Sinai New York City New YorkClare BryceDepartment of Pathology Molecular and Cell‐Based Medicine, Icahn School of Medicine at Mount Sinai New York City New YorkZachary GrimesDepartment of Pathology Molecular and Cell‐Based Medicine, Icahn School of Medicine at Mount Sinai New York City New YorkRonald E. GordonDepartment of Pathology Molecular and Cell‐Based Medicine, Icahn School of Medicine at Mount Sinai New York City New YorkJason ReidyDepartment of Pathology Molecular and Cell‐Based Medicine, Icahn School of Medicine at Mount Sinai New York City New YorkJohn A. LednickyDepartment of Environmental and Global Health College of Public Health and Health Professions, Emerging Pathogens Institute University of Florida Gainesville FloridaEmilia Mia SordilloDepartment of Pathology Molecular and Cell‐Based Medicine, Icahn School of Medicine at Mount Sinai New York City New YorkMary FowkesDepartment of Pathology Molecular and Cell‐Based Medicine, Icahn School of Medicine at Mount Sinai New York City New York
2020en
ABI
Аннотация
Neurologic sequelae can be devastating complications of respiratory viral infections. We report the presence of virus in neural and capillary endothelial cells in frontal lobe tissue obtained at postmortem examination from a patient infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Our observations of virus in neural tissue, in conjunction with clinical correlates of worsening neurologic symptoms, pave the way to a closer understanding of the pathogenic mechanisms underlying central nervous system involvement by SARS-CoV-2.
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