Статья

Molecular Mechanism for Antibody-Dependent Enhancement of Coronavirus Entry

Yushun WanDepartment of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, Minnesota, USAJian ShangDepartment of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, Minnesota, USAShihui SunLaboratory of Infection and Immunity, Beijing Institute of Microbiology and Epidemiology, Beijing, ChinaWanbo TaiLindsley F. Kimball Research Institute, New York Blood Center, New York, New York, USAJing ChenWuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei Province, ChinaQibin GengDepartment of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, Minnesota, USALei HeLaboratory of Infection and Immunity, Beijing Institute of Microbiology and Epidemiology, Beijing, ChinaYuehong ChenLaboratory of Infection and Immunity, Beijing Institute of Microbiology and Epidemiology, Beijing, ChinaJianming WuDepartment of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, Minnesota, USAZheng‐Li ShiWuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei Province, ChinaYusen ZhouLaboratory of Infection and Immunity, Beijing Institute of Microbiology and Epidemiology, Beijing, ChinaLanying DuLindsley F. Kimball Research Institute, New York Blood Center, New York, New York, USAFang LiDepartment of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, Minnesota, USA

2019en

ABI

Аннотация

Antibody-dependent enhancement (ADE) of viral entry has been observed for many viruses. It was shown that antibodies target one serotype of viruses but only subneutralize another, leading to ADE of the latter viruses. Here we identify a novel mechanism for ADE: a neutralizing antibody binds to the surface spike protein of coronaviruses like a viral receptor, triggers a conformational change of the spike, and mediates viral entry into IgG Fc receptor-expressing cells through canonical viral-receptor-dependent pathways. We further evaluated how antibody dosages impacted viral entry into cells expressing viral receptor, Fc receptor, or both receptors. This study reveals complex roles of antibodies in viral entry and can guide future vaccine design and antibody-based drug therapy.

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Идентификаторы

DOI: 10.1128/jvi.02015-19

Цитирования и источники

Цитирований: 3Использованных источников: 0

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