Non-invasive diffuse correlation tomography reveals spatial and temporal blood flow differences in murine bone grafting approaches
Songfeng HanInstitute of Optics, University of Rochester, Rochester, NY 14627, USAAshley R. ProctorDepartment of Biomedical Engineering, University of Rochester, Rochester, NY 14627, USAJoseph B. VellaDepartment of Biomedical Engineering, University of Rochester, Rochester, NY 14627, USA; Department of Orthopaedics and Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY 14642, USA; Department of Otolaryngology-Head and Neck Surgery, University of Rochester Medical Center, Rochester, NY 14642, USADanielle S. W. BenoitDepartment of Biomedical Engineering, University of Rochester, Rochester, NY 14627, USA; Department of Orthopaedics and Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY 14642, USA; Department of Chemical Engineering, University of Rochester, Rochester, NY 14627, USA; Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USARegine ChoeDepartment of Biomedical Engineering, University of Rochester, Rochester, NY 14627, USA; Department of Electrical and Computer Engineering, University of Rochester, Rochester, NY 14627, USA
2016en
ABI
Аннотация
measurements were performed. Blood flow changes in autografts, which heal successfully, were localized to graft regions and consistent across mice. Poor healing allografts showed heterogeneous blood flow elevation and high inter-subject variabilities. Allografts with tissue-engineered periosteum showed responses intermediate to both autografts and allografts, consistent with healing observed. These findings suggest that spatiotemporal blood flow changes can be utilized to differentiate the degree of bone graft healing.
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