Статья

Longitudinal 3D Blood Flow Distribution Provided by Diffuse Correlation Tomography during Bone Healing in a Murine Fracture Model

Jingxuan RenDepartment of Biomedical Engineering University of Rochester Rochester NYSongfeng HanInstitute of Optics University of Rochester Rochester NYAshley R. ProctorDepartment of Biomedical Engineering University of Rochester Rochester NYDanielle E. DesaDepartment of Biomedical Engineering University of Rochester Rochester NYGabriel RamirezDepartment of Biomedical Engineering University of Rochester Rochester NYVincent Ralph D. Ching‐RoaDepartment of Biomedical Engineering University of Rochester Rochester NYJoseph B. MajeskiDepartment of Biomedical Engineering University of Rochester Rochester NYIrfaan A. DarDepartment of Biomedical Engineering University of Rochester Rochester NYNathaniel E. BarberDepartment of Biomedical Engineering University of Rochester Rochester NYAmanda M. FortiDepartment of Biomedical Engineering University of Rochester Rochester NYDanielle S. W. BenoitDepartment of Biomedical Engineering University of Rochester Rochester NYRegine ChoeDepartment of Biomedical Engineering University of Rochester Rochester NY

2019en

ABI

Аннотация

Noninvasive monitoring of vascularization can potentially diagnose impaired bone healing earlier than current radiographic methods. In this study, a noncontact diffuse correlation tomography (DCT) technique was employed to measure longitudinal blood flow changes during bone healing in a murine femoral fracture model. The three-dimensional distribution of the relative blood flow was quantified from one day pre-fracture to 48 days post-fracture. For three mice, frequent DCT measurements were performed every other day for one week after fracture, and then weekly thereafter. A decrease in blood flow was observed in the bone fracture region at one day post-fracture, followed by a monotonic increase in blood flow beyond the pre-injury baseline until five to seven days post-fracture. For the remaining 12 mice, only weekly DCT measurements were performed. Data collected on a weekly basis show the blood flow for most mice was elevated above baseline during the first two post-fracture weeks, followed by a subsequent decrease. Torsional strength of the excised femurs was measured for all 15 mice after 7 weeks of healing. A metric based on the early blood flow changes shows a statistically significant difference between the high strength group and the low strength group.

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Идентификаторы

DOI: 10.1111/php.13201

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