Molecular Cloning and Disease Association of Hepatitis G Virus: A Transfusion-Transmissible Agent
Jeff LinnenJ. Linnen, J. Wages Jr, Z.-Y. Zhang-Keck, K. E. Fry, K. Fung, L. Young, M. Piatak Jr, C. Hoover, J. Fernandez, S. Chen, J.-C. Zou, J. D. Lifson, S. K. H. Foung, J. P. Kim, Genelabs Technologies, Redwood City, CA 94063, USAJ. WagesJ. Linnen, J. Wages Jr, Z.-Y. Zhang-Keck, K. E. Fry, K. Fung, L. Young, M. Piatak Jr, C. Hoover, J. Fernandez, S. Chen, J.-C. Zou, J. D. Lifson, S. K. H. Foung, J. P. Kim, Genelabs Technologies, Redwood City, CA 94063, USAZ Y Zhang-KeckJ. Linnen, J. Wages Jr, Z.-Y. Zhang-Keck, K. E. Fry, K. Fung, L. Young, M. Piatak Jr, C. Hoover, J. Fernandez, S. Chen, J.-C. Zou, J. D. Lifson, S. K. H. Foung, J. P. Kim, Genelabs Technologies, Redwood City, CA 94063, USAKirk E. FryJ. Linnen, J. Wages Jr, Z.-Y. Zhang-Keck, K. E. Fry, K. Fung, L. Young, M. Piatak Jr, C. Hoover, J. Fernandez, S. Chen, J.-C. Zou, J. D. Lifson, S. K. H. Foung, J. P. Kim, Genelabs Technologies, Redwood City, CA 94063, USAK. KrawczyńskiK. Z. Krawczynski, M. Gallagher, M. Alter, T. Morris, H. Margolis, Hepatitis Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USAHarvey J. AlterH. Alter, Y. Nakatsuji, J. W.-K. Shih, Department of Transfusion Medicine, National Institutes of Health, Bethesda, MD 20205, USAEugene V. KooninE. Koonin, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USAMargaret GallagherK. Z. Krawczynski, M. Gallagher, M. Alter, T. Morris, H. Margolis, Hepatitis Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USAMiriam J. AlterK. Z. Krawczynski, M. Gallagher, M. Alter, T. Morris, H. Margolis, Hepatitis Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USAStephanos J. HadziyannisS. Hadziyannis, Academic Department of Medicine, Hippokration Hospital, Athens, GreecePeter KarayiannisP. Karayiannis and H. Thomas, Department of Medicine, St. Mary's Hospital Medical School, London, UKKevin FungJ. Linnen, J. Wages Jr, Z.-Y. Zhang-Keck, K. E. Fry, K. Fung, L. Young, M. Piatak Jr, C. Hoover, J. Fernandez, S. Chen, J.-C. Zou, J. D. Lifson, S. K. H. Foung, J. P. Kim, Genelabs Technologies, Redwood City, CA 94063, USAYoshiyuki NakatsujiH. Alter, Y. Nakatsuji, J. W.-K. Shih, Department of Transfusion Medicine, National Institutes of Health, Bethesda, MD 20205, USAJ. Wai‐Kuo ShihH. Alter, Y. Nakatsuji, J. W.-K. Shih, Department of Transfusion Medicine, National Institutes of Health, Bethesda, MD 20205, USAL M YoungJ. Linnen, J. Wages Jr, Z.-Y. Zhang-Keck, K. E. Fry, K. Fung, L. Young, M. Piatak Jr, C. Hoover, J. Fernandez, S. Chen, J.-C. Zou, J. D. Lifson, S. K. H. Foung, J. P. Kim, Genelabs Technologies, Redwood City, CA 94063, USAMichael PiatakJ. Linnen, J. Wages Jr, Z.-Y. Zhang-Keck, K. E. Fry, K. Fung, L. Young, M. Piatak Jr, C. Hoover, J. Fernandez, S. Chen, J.-C. Zou, J. D. Lifson, S. K. H. Foung, J. P. Kim, Genelabs Technologies, Redwood City, CA 94063, USACameron HooverJ. Linnen, J. Wages Jr, Z.-Y. Zhang-Keck, K. E. Fry, K. Fung, L. Young, M. Piatak Jr, C. Hoover, J. Fernandez, S. Chen, J.-C. Zou, J. D. Lifson, S. K. H. Foung, J. P. Kim, Genelabs Technologies, Redwood City, CA 94063, USAJohn FernandezJ. Linnen, J. Wages Jr, Z.-Y. Zhang-Keck, K. E. Fry, K. Fung, L. Young, M. Piatak Jr, C. Hoover, J. Fernandez, S. Chen, J.-C. Zou, J. D. Lifson, S. K. H. Foung, J. P. Kim, Genelabs Technologies, Redwood City, CA 94063, USAStacie ChenJ. Linnen, J. Wages Jr, Z.-Y. Zhang-Keck, K. E. Fry, K. Fung, L. Young, M. Piatak Jr, C. Hoover, J. Fernandez, S. Chen, J.-C. Zou, J. D. Lifson, S. K. H. Foung, J. P. Kim, Genelabs Technologies, Redwood City, CA 94063, USAJian-Chao ZouJ. Linnen, J. Wages Jr, Z.-Y. Zhang-Keck, K. E. Fry, K. Fung, L. Young, M. Piatak Jr, C. Hoover, J. Fernandez, S. Chen, J.-C. Zou, J. D. Lifson, S. K. H. Foung, J. P. Kim, Genelabs Technologies, Redwood City, CA 94063, USATimothy T. MorrisK. Z. Krawczynski, M. Gallagher, M. Alter, T. Morris, H. Margolis, Hepatitis Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USAKenneth C. HyamsK. C. Hyams, Naval Medical Research Institute, Rockville, MD 20852, USAS. IsmayS. Ismay, New South Wales Red Cross Blood Transfusion Service, Sydney, AustraliaJeffrey D. LifsonJ. Linnen, J. Wages Jr, Z.-Y. Zhang-Keck, K. E. Fry, K. Fung, L. Young, M. Piatak Jr, C. Hoover, J. Fernandez, S. Chen, J.-C. Zou, J. D. Lifson, S. K. H. Foung, J. P. Kim, Genelabs Technologies, Redwood City, CA 94063, USAGeorg HeßG. Hess, Boehringer Mannheim GmbM, D68305 Mannheim, GermanySteven K. H. FoungJ. Linnen, J. Wages Jr, Z.-Y. Zhang-Keck, K. E. Fry, K. Fung, L. Young, M. Piatak Jr, C. Hoover, J. Fernandez, S. Chen, J.-C. Zou, J. D. Lifson, S. K. H. Foung, J. P. Kim, Genelabs Technologies, Redwood City, CA 94063, USAHoward ThomasP. Karayiannis and H. Thomas, Department of Medicine, St. Mary's Hospital Medical School, London, UKDaniel W. BradleyD. Bradley, 2938 Kelly Court, Lawrenceville, GA 30244, USAHarold S. MargolisK. Z. Krawczynski, M. Gallagher, M. Alter, T. Morris, H. Margolis, Hepatitis Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USAJungsuh P. KimJ. Linnen, J. Wages Jr, Z.-Y. Zhang-Keck, K. E. Fry, K. Fung, L. Young, M. Piatak Jr, C. Hoover, J. Fernandez, S. Chen, J.-C. Zou, J. D. Lifson, S. K. H. Foung, J. P. Kim, Genelabs Technologies, Redwood City, CA 94063, USA
1996en
ABI
Аннотация
An RNA virus, designated hepatitis G virus (HGV), was identified from the plasma of a patient with chronic hepatitis. Extension from an immunoreactive complementary DNA clone yielded the entire genome (9392 nucleotides) encoding a polyprotein of 2873 amino acids. The virus is closely related to GB virus C (GBV-C) and distantly related to hepatitis C virus, GBV-A, and GBV-B. HGV was associated with acute and chronic hepatitis. Persistent viremia was detected for up to 9 years in patients with hepatitis. The virus is transfusion-transmissible. It has a global distribution and is present within the volunteer blood donor population in the United States.
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