Enhanced biocompatibility for plasmid DNA on patterned TiO2 surfaces

An enhanced biocompatibility from nanodot patterned TiO2 surfaces, fabricated by ion beam sputtering, has been observed here through its interaction with plasmid DNA. Investigations of the persistence length and the areal conformation of DNA show that the biocompatibility increases with ion fluence. Presence of nanostructures and increased surface roughness, in conjugation with higher oxygen vacancy sites that promote charge transfer from DNA moiety, are responsible for the increased hydrophilicity and biocompatibility of the patterned surfaces.

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