Genetic-Epidemiologic Study of Haemophilia A and B in Hungary
L. Istv aacute nDepartment of Blood Transfusion, Markusovszky Hospital of County Vas, SzombathelyAndrew E. CzeizelDepartment of Human Genetics and Teratology, WHO Collaborating Centre for the Community Control of Hereditary Diseases, National Institute of Hygiene, Budapest;M. Ker eacute nyiHospital of County Zala, Zalaegerszeg;A.M. T oacute thHospital of County Veszprém, Veszprém;E Domby
1990en
ABI
Аннотация
All known surviving haemophiliacs A and B and their relatives were reexamined by laboratory and clinical methods and evaluated by a genetic-epidemiologic approach in 4 north-western countries of Hungary. The prevalence of haemophilia A and B patients born in the fifties was 2.73 and 0.25 per 10,000 persons, respectively. The reproductive fitness was found to be 0.3 in haemophilia A, and 0.8 in haemophilia B patients. The mutation rates calculated by the indirect method were 6.3 x 10(-5) for haemophilia A and 0.2 x 10(-5) for haemophilia B.
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