Hydrophobic Regions on the Active Surface of Choline-esterases

The methods of synthesis of S-alkyl(aryl) derivatives of methylphosphonothioic acid and methods for the investigation of their anticholine-esterase activity have been briefly described. Data confirming the anticholine-esterase activity of the compounds synthesised are presented. It has been shown that, in the inhibition of choline-esterases by organophosphorus compounds, the hydrophobic sorption of these substances on the active surface of the enzymes plays an important and sometimes a decisive role. It is suggested that the presence of hydrophobic regions on the active surface of choline-esterases tends to increase the probability of the sorption of acetylcholine (a choline esterase substrate) on this surface. The bibliography includes 68 references.

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