Статья

Bioactive Saponins and Glycosides. II. Senegae Radix. (2): Chemical Structures, Hypoglycemic Activity, and Ethanol Absorption-Inhibitory Effect of E-Senegasaponin c, Z-Senegasaponin c, and Z-Senegins II, III, and IV.

Masayuki YOSHIKAWAKyoto Pharmaceutical University, JapanToshiyuki MURAKAMIKyoto Pharmaceutical University, Kyoto Pharmaceutical University, Kyoto Pharmaceutical University, Kyoto Pharmaceutical University, Kyoto Pharmaceutical University, Kyoto Pharmaceutical University, Kyoto Pharmaceutical UniversityHisashi MatsudaKyoto Pharmaceutical University, Kyoto Pharmaceutical University, Kyoto Pharmaceutical University, Kyoto Pharmaceutical University, Kyoto Pharmaceutical University, Kyoto Pharmaceutical University, Kyoto Pharmaceutical UniversityTakahiro UenoKyoto Pharmaceutical University, Kyoto Pharmaceutical University, Kyoto Pharmaceutical University, Kyoto Pharmaceutical University, Kyoto Pharmaceutical University, Kyoto Pharmaceutical University, Kyoto Pharmaceutical UniversityMasashi KADOYAKyoto Pharmaceutical University, Kyoto Pharmaceutical University, Kyoto Pharmaceutical University, Kyoto Pharmaceutical University, Kyoto Pharmaceutical University, Kyoto Pharmaceutical University, Kyoto Pharmaceutical UniversityJohji YAMAHARAKyoto Pharmaceutical University, Kyoto Pharmaceutical University, Kyoto Pharmaceutical University, Kyoto Pharmaceutical University, Kyoto Pharmaceutical University, Kyoto Pharmaceutical University, Kyoto Pharmaceutical UniversityNobutoshi MURAKAMIKyoto Pharmaceutical University, Kyoto Pharmaceutical University, Kyoto Pharmaceutical University, Kyoto Pharmaceutical University, Kyoto Pharmaceutical University, Kyoto Pharmaceutical University, Kyoto Pharmaceutical University

1996en

ABI

Аннотация

Following the characterization of E-senegasaponins a and b and Z-senegasaponins a and b, new bioactive saponins named E-senegasaponin c and Z-senegasaponin c were isolated from Senegae Radix, the root of Polygala senega L. var. latifolia TORREY et GRAY., together with Z-senegins II, III, and IV. The chemical structures of E and Z-senegasaponins c and Z-senegins II, III, and IV were elucidated on the basis of chemical and physicochemical evidence, and the geometrical isomeric structures of the 4"-methoxycinnamoyl and 3",4"-dimethoxycinnamoyl groups in these saponins were found to show tautomer-like behavior under irradiation with fluorescent lamps. E and Z-Senegasaponins c and E and Z-senegins II, III, and IV were found to exhibit hypoglycemic activity in the oral D-glucose tolerance test. (E) and (Z)-Senegins II also showed an inhibitory effect on alcohol absorption in rats.

Перевод пока недоступен

Идентификаторы

DOI: 10.1248/cpb.44.1305

Цитирования и источники

Цитирований: 2Использованных источников: 0

Показатели — AkademScholar