Статья

From pituitary adenoma to pituitary neuroendocrine tumor (PitNET): an International Pituitary Pathology Club proposal

L. SylviaDepartment of Pathology and Endocrine Oncology Site GroupPrincess Margaret Cancer Centre, University Health Network, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada [email protected] [email protected]Olivera Casar‐BorotaDepartment of PathologyUppsala University Hospital, Uppsala, SwedenPhilippe ChansonService of Endocrinology and Reproductive DiseasesBicêtre Hospital, Paris, FranceEtienne DelgrangeDepartment of MedicineUniversity of Louvain, Mont-sur-Meuse, BelgiumPeter EarlsDepartment of Anatomical PathologySt Vincent's Hospital, Sydney, AustraliaShereen EzzatDepartment of Medicine and Endocrine Oncology Site GroupPrincess Margaret Cancer Centre, University Health Network and University of Toronto, Toronto, Ontario, CanadaAshley GrossmanDepartment of EndocrinologyUniversity of Oxford, Oxford, UKHidetoshi IkedaResearch Institute for Pituitary DiseaseSouthern Tohoku General Hospital, Fukushima, JapanNaoko InoshitaDepartment of PathologyToranomon Hospital, Tokyo, JapanNiki KaravitakiDepartment of EndocrinologyQueen Elizabeth Hospital, University of Birmingham, Birmingham, UKMárta KorbonitsDivision of EndocrinologyQueen Mary Hospital, Barts and the London School of Medicine, London, UKEdward R. LawsDepartment of NeurosurgeryHarvard Medical School, Brigham & Women's Hospital, Boston, Massachusetts, USAM. Beatriz S. LopesDepartments of Pathology and Neurological SurgeryUniversity of Virginia, Charlottesville, Virginia, USANiki MaartensDepartment of NeurosurgeryRoyal Melbourne Hospital, The University of Melbourne, Melbourne, AustraliaIan E. McCutcheonDepartment of NeurosurgeryUT MD Anderson Cancer Center, Houston, Texas, USAÖzgür MeteDepartment of Pathology and Endocrine Oncology Site GroupPrincess Margaret Cancer Centre, University Health Network, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, CanadaHiroshi NishiokaDepartment of NeurosurgeryToranomon Hospital, Tokyo, JapanGérald RaverotDepartment of EndocrinologyGroupement Hospitalier EST, Hospices Civils de Lyon, University of Lyon, Lyon, FranceFederico RoncaroliDepartment of NeuropathologyImperial College, London, UKWolfgang SaegerInstitute of Neuropathology of the University of HamburgHamburg, GermanyLuis V. SyroDepartment of NeurosurgeryHospital Pablo Tobon Uribe, Medellin, ColombiaAlexandre VasiljevicDepartment of PathologyGroupement Hospitalier EST, Hospices Civils de Lyon, University of Lyon, Lyon, FranceChiara VillaDepartment of PathologyHôpital Foch, Suresnes, FranceAnne WierinckxINSERM U1052Cancer Research Center of Lyon, University of Lyon, Lyon, FranceJacqueline TrouillasFaculty of Medicine Lyon-EstUniversity of Lyon, Lyon, France [email protected] [email protected]_ _

2017en

ABI

Аннотация

The classification of neoplasms of adenohypophysial cells is misleading because of the simplistic distinction between adenoma and carcinoma, based solely on metastatic spread and the poor reproducibility and predictive value of the definition of atypical adenomas based on the detection of mitoses or expression of Ki-67 or p53. In addition, the current classification of neoplasms of the anterior pituitary does not accurately reflect the clinical spectrum of behavior. Invasion and regrowth of proliferative lesions and persistence of hormone hypersecretion cause significant morbidity and mortality. We propose a new terminology, pituitary neuroendocrine tumor (PitNET), which is consistent with that used for other neuroendocrine neoplasms and which recognizes the highly variable impact of these tumors on patients.

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Идентификаторы

DOI: 10.1530/erc-17-0004

Цитирования и источники

Цитирований: 2Использованных источников: 0

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