STUDY THE ANTIFIBROUS EFFICACY OF PLANT PROANTHOCYANIDIN IN RATS WITH CHRONIC HELIOTRINE LIVER DAMAGE

Under experimental conditions, the effect of plant proanthocyanidin – yantacin isolated from a camel thorn plant (Alhagi pseudalhagi) – Yantacin, when administered orally at a dose of 100 mg / kg, on possible changes in the early stages of liver fibrosis that occurred against the background of chronic heliotrine hepatitis was studied. The studies were conducted on male rats with a body weight of 100 ±10 g. The effect of yantacin on the general and biochemical parameters of the blood, as well as the amount of NO – nitrates (in connection with lipoproteins), proteins in the blood against the background of heliotrine liver damage was studied. At the same time, yantacin demonstrated a significant protective effect compared to the control group on the detected fibrosis, according to which certain indicators, against the background of chronic toxic liver damage. In this regard, a more extensive in-depth study of the effect of the studied substance plant proanthocyanidin on normal and impaired liver activity is carried out.

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