Applications of magnetic nanoparticles in biomedicine
Quentin A. PankhurstDepartment of Physics and Astronomy, and London Centre for Nanotechnology, University College London, Gower Street, London WC1E 6BT, UKJoan ConnollyDepartment of Applied Physics, Curtin University of Technology, GPO Box U1987, Perth 6845, Western AustraliaStephen JonesSIRTeX Medical Limited, PO Box 760, North Ryde, New South Wales 2113, AustraliaJon DobsonDepartment of Biomedical Engineering and Medical Physics, Centre for Science and Technology in Medicine, Keele University, Stoke-on-Trent ST4 7QB, UK
2003en
ABI
Аннотация
The physical principles underlying some current biomedical applications of magnetic nanoparticles are reviewed. Starting from well-known basic concepts, and drawing on examples from biology and biomedicine, the relevant physics of magnetic materials and their responses to applied magnetic fields are surveyed. The way these properties are controlled and used is illustrated with reference to (i) magnetic separation of labelled cells and other biological entities; (ii) therapeutic drug, gene and radionuclide delivery; (iii) radio frequency methods for the catabolism of tumours via hyperthermia; and (iv) contrast enhancement agents for magnetic resonance imaging applications. Future prospects are also discussed.
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