RELEASE OF LUTEINIZING HORMONE FROM THE ANTERIOR HYPOPHYSIS BY AN ACETYLCHOLINE-LIKE SUBSTANCE FROM THE HYPOTHALAMIC REGION

THE RECENT RAPID advances in the knowledge and in the availability of endocrine products for therapeutic use have tended to submerge interest in other aspects of the physiology of sex. However, the relationship between the nervous system and sex function in women is generally recognized, and is perhaps best exemplified by the well known effects of mental, emotional and physical strain on the menstrual cycle. Our interest in the role of the nervous system and in the therapeutic possibilities of drugs which affect this system was stimulated by our previous work on the relation of hyperemia to the action of estrin (1) and the use of prostigmine to precipitate menstrual flow in cases of ‘nervous’ amenorrhea (2). Because of the difficulties inherent in the use of human subjects, the present work on rats was under-taken in an attempt to amplify the knowledge of the nervous system and endocrine relationships, and to clarify the mechanism by which prostigmine could produce the above mentioned effect.

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