Статья

Antimicrobial Activity of Two Different Types of Silver Nanoparticles against Wide Range of Pathogenic Bacteria

Viktoriia HolubnychaMedical Institute, Sumy State University, 2, Rymskogo-Korsakova St., 40007 Sumy, UkraineYevheniia HusakFaculty of Chemistry, Silesian University of Technology, 44-100 Gliwice, PolandViktoriia KorniienkoInstitute of Atomic Physics and Spectroscopy, University of Latvia, 3 Jelgavas St., LV-1004 Riga, LatviaSvitlana BolshaninaMedical Institute, Sumy State University, 2, Rymskogo-Korsakova St., 40007 Sumy, UkraineOlesia TveresovskaMedical Institute, Sumy State University, 2, Rymskogo-Korsakova St., 40007 Sumy, UkraineP. F. MyronovMedical Institute, Sumy State University, 2, Rymskogo-Korsakova St., 40007 Sumy, UkraineMarharyta HolubnychaMedical Institute, Sumy State University, 2, Rymskogo-Korsakova St., 40007 Sumy, UkraineAnna ButsykDepartment Medical Biochemistry and Biophysics, Umeå University, SE-901 87 Umeå, SwedenThomas BorénDepartment Medical Biochemistry and Biophysics, Umeå University, SE-901 87 Umeå, SwedenRafał BanasiukMechanical Faculty, Gdańsk University of Technology, G. Narutowicza 11/12, 80-233 Gdańsk, PolandArūnas RamanavičiusDepartment of Physical Chemistry, Institute of Chemistry, Faculty of Chemistry and Geosciences, Vilnius University, Naugarduko Str. 24, LT-03225 Vilnius, LithuaniaMaksym PogorielovInstitute of Atomic Physics and Spectroscopy, University of Latvia, 3 Jelgavas St., LV-1004 Riga, Latvia

2024en

ABI

Аннотация

spp. (ESKAPE)-pathogens pose a significant threat to global health. Current antimicrobial therapies, including those targeting biofilms, have shown limited effectiveness against these superbugs. Nanoparticles, specifically silver nanoparticles (AgNPs), have emerged as a promising alternative for combating bacterial infections. In this study, two types of AgNPs with different physic-chemical properties were evaluated for their antimicrobial and antibiofilm activities against clinical ESKAPE strains. Two types of silver nanoparticles were assessed: spherical silver nanoparticles (AgNPs-1) and cubic-shaped silver nanoparticles (AgNPs-2). AgNPs-2, characterized by a cubic shape and higher surface-area-to-volume ratio, exhibited superior antimicrobial activity compared to spherical AgNPs-1. Both types of AgNPs demonstrated the ability to inhibit biofilm formation and disrupt established biofilms, leading to membrane damage and reduced viability of the bacteria. These findings highlight the potential of AgNPs as effective antibacterial agents against ESKAPE pathogens, emphasizing the importance of nanoparticle characteristics in determining their antimicrobial properties. Further research is warranted to explore the underlying mechanisms and optimize nanoparticle-based therapies for the management of infections caused by antibiotic-resistant bacteria.

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Идентификаторы

DOI: 10.3390/nano14020137

Цитирования и источники

Цитирований: 2Использованных источников: 0

Показатели — AkademScholar