Статья

Jatrophane Diterpenes from <i>Euphorbia esula</i> as Antiproliferative Agents and Potent Chemosensitizers to Overcome Multidrug Resistance

Andrea VasasDepartment of Pharmacognosy, University of Szeged, Eötvös u. 6, H-6720 Szeged, HungaryE SulyokDepartment of Pharmacognosy, University of Szeged, Eötvös u. 6, H-6720 Szeged, HungaryDóra RédeiDepartment of Pharmacognosy, University of Szeged, Eötvös u. 6, H-6720 Szeged, HungaryPéter ForgóDepartment of Pharmacognosy, University of Szeged, Eötvös u. 6, H-6720 Szeged, HungaryPál SzabóInstitute of Chemistry, Chemical Research Centre, Hungarian Academy of Sciences, H-1525 Budapest, HungaryIstván ZupkóDepartment of Pharmacodynamics and Biopharmacy, University of Szeged, H-6720 Szeged, HungaryÁgnes BerényiDepartment of Pharmacodynamics and Biopharmacy, University of Szeged, H-6720 Szeged, HungaryJoséph MolnárDepartment of Medical Microbiology and Immunobiology, University of Szeged, H-6720 Szeged, HungaryJudit HohmannDepartment of Pharmacognosy, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary

2011en

ABI

Аннотация

Phytochemical study of whole, undried plants of Euphorbia esula led to the isolation of six new (1-6) jatrophane diterpene polyesters, named esulatins H-M, together with the known compounds 2α,3β,5α,7β,15β-pentaacetoxy-9α-nicotinoyloxyjatropha-6(17),11-dien-14-one (7), salicinolide (8), and euphosalicin (9). The structures and relative configuration of 1-6 were established on the basis of extensive spectroscopic analysis, including HRESIMS and one- and two-dimensional NMR techniques. All these compounds, together with diterpenes (10-14) isolated previously from this plant, were evaluated for their antiproliferative activity against HeLa, Ishikawa, and MCF7 cells. The multidrug-resistance-reversing activities were also investigated on L5178 mouse lymphoma cells transfected with the pHa MDR1/A retrovirus DNA. Preliminary structure-activity relationship data are discussed.

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Идентификаторы

DOI: 10.1021/np200202h

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Цитирований: 2Использованных источников: 0

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