Euphorbesulins A–P, Structurally Diverse Diterpenoids from <i>Euphorbia esula</i>
Bin ZhouState
Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, People’s Republic of ChinaYan WuState
Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, People’s Republic of ChinaSeema DalalDepartment
of Biochemistry and the Virginia Tech Center for Drug Discovery, MC
0308, Virginia Tech, Blacksburg, Virginia 24061, United StatesMaría B. CasseraDepartment
of Biochemistry and the Virginia Tech Center for Drug Discovery, MC
0308, Virginia Tech, Blacksburg, Virginia 24061, United StatesJian‐Min YueState
Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, People’s Republic of China
2016en
ABI
Аннотация
Aqueous ethanol extracts of powdered twigs of Euphorbia esula afforded 16 new diterpenoids, named euphorbesulins A-P. These euphorbesulins included presegetane (1-3), jatrophane (4-14), paraliane (15), and isopimarane (16) diterpenoids as well as six known analogues. Compounds 1-3 represent a rare type of presegetane diterpenoid. Their structures were determined by analysis of the spectroscopic data, and the absolute configuration of 1 was established by X-ray crystallography. Diterpenoid 7 showed low nanomolar antimalarial activity, while the remaining compounds showed only moderate or no antimalarial activity.
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