Gene Expression Signature–Based Prognostic Risk Score in Gastric Cancer
Y. ChoiAuthors' Affiliations: Departments of 1Systems Biology, 2Thoracic/Head and Neck Medical Oncology, and 3Gastrointestinal Medical Oncology, Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, Texas; Departments of 4Medical Oncology, 5Surgery, and 6Pathology, Yonsei University College of Medicine, Seoul; 7Department of Biological Science, Dong-A University, Busan; 8Korean Bioinformation Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon; and 9Department of Physiology, Chonbuk National University Medical School and Hospital, Jeonju, KoreaJae Yun LimAuthors' Affiliations: Departments of 1Systems Biology, 2Thoracic/Head and Neck Medical Oncology, and 3Gastrointestinal Medical Oncology, Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, Texas; Departments of 4Medical Oncology, 5Surgery, and 6Pathology, Yonsei University College of Medicine, Seoul; 7Department of Biological Science, Dong-A University, Busan; 8Korean Bioinformation Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon; and 9Department of Physiology, Chonbuk National University Medical School and Hospital, Jeonju, KoreaJae‐Ho CheongAuthors' Affiliations: Departments of 1Systems Biology, 2Thoracic/Head and Neck Medical Oncology, and 3Gastrointestinal Medical Oncology, Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, Texas; Departments of 4Medical Oncology, 5Surgery, and 6Pathology, Yonsei University College of Medicine, Seoul; 7Department of Biological Science, Dong-A University, Busan; 8Korean Bioinformation Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon; and 9Department of Physiology, Chonbuk National University Medical School and Hospital, Jeonju, KoreaYun‐Yong ParkAuthors' Affiliations: Departments of 1Systems Biology, 2Thoracic/Head and Neck Medical Oncology, and 3Gastrointestinal Medical Oncology, Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, Texas; Departments of 4Medical Oncology, 5Surgery, and 6Pathology, Yonsei University College of Medicine, Seoul; 7Department of Biological Science, Dong-A University, Busan; 8Korean Bioinformation Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon; and 9Department of Physiology, Chonbuk National University Medical School and Hospital, Jeonju, KoreaSe-Lyun YoonAuthors' Affiliations: Departments of 1Systems Biology, 2Thoracic/Head and Neck Medical Oncology, and 3Gastrointestinal Medical Oncology, Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, Texas; Departments of 4Medical Oncology, 5Surgery, and 6Pathology, Yonsei University College of Medicine, Seoul; 7Department of Biological Science, Dong-A University, Busan; 8Korean Bioinformation Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon; and 9Department of Physiology, Chonbuk National University Medical School and Hospital, Jeonju, KoreaSoo Mi KimAuthors' Affiliations: Departments of 1Systems Biology, 2Thoracic/Head and Neck Medical Oncology, and 3Gastrointestinal Medical Oncology, Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, Texas; Departments of 4Medical Oncology, 5Surgery, and 6Pathology, Yonsei University College of Medicine, Seoul; 7Department of Biological Science, Dong-A University, Busan; 8Korean Bioinformation Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon; and 9Department of Physiology, Chonbuk National University Medical School and Hospital, Jeonju, KoreaSang-Bae KimAuthors' Affiliations: Departments of 1Systems Biology, 2Thoracic/Head and Neck Medical Oncology, and 3Gastrointestinal Medical Oncology, Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, Texas; Departments of 4Medical Oncology, 5Surgery, and 6Pathology, Yonsei University College of Medicine, Seoul; 7Department of Biological Science, Dong-A University, Busan; 8Korean Bioinformation Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon; and 9Department of Physiology, Chonbuk National University Medical School and Hospital, Jeonju, KoreaHoguen KimAuthors' Affiliations: Departments of 1Systems Biology, 2Thoracic/Head and Neck Medical Oncology, and 3Gastrointestinal Medical Oncology, Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, Texas; Departments of 4Medical Oncology, 5Surgery, and 6Pathology, Yonsei University College of Medicine, Seoul; 7Department of Biological Science, Dong-A University, Busan; 8Korean Bioinformation Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon; and 9Department of Physiology, Chonbuk National University Medical School and Hospital, Jeonju, KoreaSoon Won HongAuthors' Affiliations: Departments of 1Systems Biology, 2Thoracic/Head and Neck Medical Oncology, and 3Gastrointestinal Medical Oncology, Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, Texas; Departments of 4Medical Oncology, 5Surgery, and 6Pathology, Yonsei University College of Medicine, Seoul; 7Department of Biological Science, Dong-A University, Busan; 8Korean Bioinformation Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon; and 9Department of Physiology, Chonbuk National University Medical School and Hospital, Jeonju, KoreaYoung Nyun ParkAuthors' Affiliations: Departments of 1Systems Biology, 2Thoracic/Head and Neck Medical Oncology, and 3Gastrointestinal Medical Oncology, Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, Texas; Departments of 4Medical Oncology, 5Surgery, and 6Pathology, Yonsei University College of Medicine, Seoul; 7Department of Biological Science, Dong-A University, Busan; 8Korean Bioinformation Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon; and 9Department of Physiology, Chonbuk National University Medical School and Hospital, Jeonju, KoreaSung Hoon NohAuthors' Affiliations: Departments of 1Systems Biology, 2Thoracic/Head and Neck Medical Oncology, and 3Gastrointestinal Medical Oncology, Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, Texas; Departments of 4Medical Oncology, 5Surgery, and 6Pathology, Yonsei University College of Medicine, Seoul; 7Department of Biological Science, Dong-A University, Busan; 8Korean Bioinformation Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon; and 9Department of Physiology, Chonbuk National University Medical School and Hospital, Jeonju, KoreaEun Sung ParkAuthors' Affiliations: Departments of 1Systems Biology, 2Thoracic/Head and Neck Medical Oncology, and 3Gastrointestinal Medical Oncology, Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, Texas; Departments of 4Medical Oncology, 5Surgery, and 6Pathology, Yonsei University College of Medicine, Seoul; 7Department of Biological Science, Dong-A University, Busan; 8Korean Bioinformation Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon; and 9Department of Physiology, Chonbuk National University Medical School and Hospital, Jeonju, KoreaIn‐Sun ChuAuthors' Affiliations: Departments of 1Systems Biology, 2Thoracic/Head and Neck Medical Oncology, and 3Gastrointestinal Medical Oncology, Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, Texas; Departments of 4Medical Oncology, 5Surgery, and 6Pathology, Yonsei University College of Medicine, Seoul; 7Department of Biological Science, Dong-A University, Busan; 8Korean Bioinformation Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon; and 9Department of Physiology, Chonbuk National University Medical School and Hospital, Jeonju, KoreaWaun Ki HongAuthors' Affiliations: Departments of 1Systems Biology, 2Thoracic/Head and Neck Medical Oncology, and 3Gastrointestinal Medical Oncology, Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, Texas; Departments of 4Medical Oncology, 5Surgery, and 6Pathology, Yonsei University College of Medicine, Seoul; 7Department of Biological Science, Dong-A University, Busan; 8Korean Bioinformation Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon; and 9Department of Physiology, Chonbuk National University Medical School and Hospital, Jeonju, KoreaJaffer A. AjaniAuthors' Affiliations: Departments of 1Systems Biology, 2Thoracic/Head and Neck Medical Oncology, and 3Gastrointestinal Medical Oncology, Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, Texas; Departments of 4Medical Oncology, 5Surgery, and 6Pathology, Yonsei University College of Medicine, Seoul; 7Department of Biological Science, Dong-A University, Busan; 8Korean Bioinformation Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon; and 9Department of Physiology, Chonbuk National University Medical School and Hospital, Jeonju, KoreaJu‐Seog LeeAuthors' Affiliations: Departments of 1Systems Biology, 2Thoracic/Head and Neck Medical Oncology, and 3Gastrointestinal Medical Oncology, Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, Texas; Departments of 4Medical Oncology, 5Surgery, and 6Pathology, Yonsei University College of Medicine, Seoul; 7Department of Biological Science, Dong-A University, Busan; 8Korean Bioinformation Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon; and 9Department of Physiology, Chonbuk National University Medical School and Hospital, Jeonju, Korea
2011en
ABI
Аннотация
PURPOSE: Despite continual efforts to develop a prognostic model of gastric cancer by using clinical and pathologic parameters, a clinical test that can discriminate patients with good outcomes from those with poor outcomes after gastric cancer surgery has not been established. We aim to develop practical biomarker-based risk score that can predict relapse of gastric cancer after surgical treatment. EXPERIMENTAL DESIGN: Microarray technologies were used to generate and analyze gene expression profiling data from 65 gastric cancer patients to identify biomarker genes associated with relapse. The association of expression patterns of identified genes with relapse and overall survival was validated in independent gastric cancer patients. RESULTS: We uncovered two subgroups of gastric cancer that were strongly associated with the prognosis. For the easy translation of our findings into practice, we developed a scoring system based on the expression of six genes that predicted the likelihood of relapse after curative resection. In multivariate analysis, the risk score was an independent predictor of relapse in a cohort of 96 patients. We were able to validate the robustness of the six-gene signature in an additional independent cohort. CONCLUSIONS: The risk score derived from the six-gene set successfully prognosticated the relapse of gastric cancer patients after gastrectomy.
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