Статья

Dynamic Disulfide Bond Regulated Tough Adhesion and On-Demand Debonding of the Albumin-Based Double Network Hydrogel to Diverse Substrates

Ziqing TangWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325000, ChinaLiu ZhaoSchool of Materials Science and Engineering, Henan Polytechnic University, Jiaozuo 454000, ChinaMin YouWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325000, ChinaHaiyan YinWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325000, ChinaHui YuWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325000, ChinaXinlei ShiWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325000, ChinaJia YangSchool of Materials Science and Engineering, Henan Polytechnic University, Jiaozuo 454000, ChinaGang QinSchool of Materials Science and Engineering, Henan Polytechnic University, Jiaozuo 454000, ChinaLin ZhuQiang ChenWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325000, China

2024en

ABI

Аннотация

The controllable tough adhesion of hydrogels and solid surfaces is essential for the development of soft-rigid hybrid medical devices. However, controllability is challenging for numerous tough adhesive hydrogels. Here, we develop a tough adhesion double network hydrogel based on bovine serum albumin and polyacrylamide (BSA/PAAm DN gel) with adjustable and robust adhesion toward diverse solid substrates because of the dynamic disulfide bonds (−S–S–). The albumin-based double network hydrogel simultaneously shows superior bulk toughness and interfacial toughness. To prepare the BSA/PAAm DN gel, the solid substrate is first modified with a silane coupling agent containing sulfhydryl, and then, the BSA/PAAm DN gel is in situ polymerized on the modified solid substrate. During the formation and destruction of disulfide bonds, the BSA/PAAm DN gel is attained between the surface of the hydrogel and modified solid substrates with reversible adhesion and on-demand debonding. The tough interfacial toughness of BSA/PAAm DN gel on diverse solid substrates exceeds 1000 J m–2, and the adhesion energy even reaches 5000 J m–2 for glass. This double network hydrogel based on the protein and polymer provides insights into the application of tough adhesion hydrogels for hybrid medical devices.

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Идентификаторы

DOI: 10.1021/acsapm.3c02002

Цитирования и источники

Цитирований: 2Использованных источников: 0

Показатели — AkademScholar