Статья

Hematogenous dissemination of glioblastoma multiforme

Carolin MüllerDepartment of Tumor Biology, University Medical Center Hamburg-Eppendorf, D-201246 Hamburg, GermanyJohannes HoltschmidtDepartment of Tumor Biology, University Medical Center Hamburg-Eppendorf, D-201246 Hamburg, GermanyMartina AuerInstitute of Human Genetics, Medical University of Graz, A-8010 Graz, AustriaEllen HeitzerInstitute of Human Genetics, Medical University of Graz, A-8010 Graz, AustriaKatrin LamszusDepartment of Neurosurgery, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg, GermanyAlexander SchulteDepartment of Neurosurgery, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg, GermanyJakob MatschkeInstitute of Neuropathology, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg, GermanySabine Langer-FreitagInstitute of Human Genetics, Technical University of Munich, D-81675 Munich, GermanyChristin GaschDepartment of Tumor Biology, University Medical Center Hamburg-Eppendorf, D-201246 Hamburg, GermanyMalgorzata StoupiecDepartment of Tumor Biology, University Medical Center Hamburg-Eppendorf, D-201246 Hamburg, GermanyOliver MauermannDepartment of Tumor Biology, University Medical Center Hamburg-Eppendorf, D-201246 Hamburg, GermanySven PeineDepartment of Transfusion Medicine, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg, GermanyMarkus GlatzelInstitute of Neuropathology, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg, GermanyMichael R. SpeicherInstitute of Human Genetics, Medical University of Graz, A-8010 Graz, AustriaJochen B. GeiglInstitute of Human Genetics, Medical University of Graz, A-8010 Graz, AustriaManfred WestphalDepartment of Neurosurgery, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg, GermanyKlaus PantelDepartment of Tumor Biology, University Medical Center Hamburg-Eppendorf, D-201246 Hamburg, GermanySabine RiethdorfDepartment of Tumor Biology, University Medical Center Hamburg-Eppendorf, D-201246 Hamburg, Germany

2014en

ABI

Аннотация

Glioblastoma multiforme (GBM) is the most frequent and aggressive brain tumor in adults. The dogma that GBM spread is restricted to the brain was challenged by reports on extracranial metastases after organ transplantation from GBM donors. We identified circulating tumor cells (CTCs) in peripheral blood (PB) from 29 of 141 (20.6%) GBM patients by immunostaining of enriched mononuclear cells with antibodies directed against glial fibrillary acidic protein (GFAP). Tumor cell spread was not significantly enhanced by surgical intervention. The tumor nature of GFAP-positive cells was supported by the absence of those cells in healthy volunteers and the presence of tumor-specific aberrations such as EGFR gene amplification and gains and losses in genomic regions of chromosomes 7 and 10. Release of CTCs was associated with EGFR gene amplification, suggesting a growth potential of these cells. We demonstrate that hematogenous GBM spread is an intrinsic feature of GBM biology.

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Идентификаторы

DOI: 10.1126/scitranslmed.3009095

Цитирования и источники

Цитирований: 2Использованных источников: 0

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