Обзорная статья

EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood

Michael WellerDepartment of Neurology, Clinical Neuroscience Center, University Hospital and University of Zurich, Zurich, Switzerland. [email protected]Martin J. van den BentBrain Tumor Center at Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, NetherlandsMatthias PreusserDivision of Oncology, Department of Medicine I, Medical University of Vienna, Vienna, AustriaÉmilie Le RhunCentre Hospitalier Universitaire (CHU) Lille, Neuro-Oncology, General and Stereotaxic Neurosurgery Service, Lille, FranceJörg C. TonnDepartment of Neurosurgery, University Hospital Munich LMU, Munich, GermanyGiuseppe MinnitiRadiation Oncology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, ItalyMartin BendszusDepartment of Neuroradiology, University Hospital Heidelberg, Heidelberg, GermanyCarmen BalañáCatalan Institute of Oncology (ICO), Hospital Germans Trias i Pujol, Badalona, SpainOlivier ChinotAix-Marseille Université, Assistance Publique-Hôpitaux de Marseille (APHM), CHU Timone, Department of Neuro-Oncology, Marseille, FranceLinda DirvenDepartment of Neurology, Haaglanden Medical Center, The Hague, NetherlandsPim J. FrenchDepartment of Neurology, Erasmus MC, Rotterdam, NetherlandsMonika E. HegiAsgeir Store JakolaDepartment of Neurosurgery, Sahlgrenska University Hospital, Gothenburg, SwedenMichael PlattenDepartment of Neurology, Medical Faculty Mannheim, Mannheim Center for Translational Neuroscience (MCTN), Heidelberg University, Mannheim, GermanyPatrick RothDepartment of Neurology, Clinical Neuroscience Center, University Hospital and University of Zurich, Zurich, SwitzerlandRoberta RudàSusan ShortLeeds Institute of Medical Research, St James's University Hospital, Leeds, UKMarion SmitsDepartment of Radiology and Nuclear Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, NetherlandsMartin TaphoornDepartment of Neurology, Haaglanden Medical Center, The Hague, NetherlandsAndreas von DeimlingDKTK and Clinical Cooperation Unit Neuropathology, DKFZ, Heidelberg, GermanyManfred WestphalDepartment of Neurosurgery, University Hospital Hamburg, Hamburg, GermanyRiccardo SoffiettiGuido ReifenbergerDKTK partner site Essen/Düsseldorf, Düsseldorf, GermanyWolfgang WickDKTK and Clinical Cooperation Unit Neurooncology, DKFZ, Heidelberg, Germany

2020en

ABI

Аннотация

In response to major changes in diagnostic algorithms and the publication of mature results from various large clinical trials, the European Association of Neuro-Oncology (EANO) recognized the need to provide updated guidelines for the diagnosis and management of adult patients with diffuse gliomas. Through these evidence-based guidelines, a task force of EANO provides recommendations for the diagnosis, treatment and follow-up of adult patients with diffuse gliomas. The diagnostic component is based on the 2016 update of the WHO Classification of Tumors of the Central Nervous System and the subsequent recommendations of the Consortium to Inform Molecular and Practical Approaches to CNS Tumour Taxonomy - Not Officially WHO (cIMPACT-NOW). With regard to therapy, we formulated recommendations based on the results from the latest practice-changing clinical trials and also provide guidance for neuropathological and neuroradiological assessment. In these guidelines, we define the role of the major treatment modalities of surgery, radiotherapy and systemic pharmacotherapy, covering current advances and cognizant that unnecessary interventions and expenses should be avoided. This document is intended to be a source of reference for professionals involved in the management of adult patients with diffuse gliomas, for patients and caregivers, and for health-care providers.

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Идентификаторы

DOI: 10.1038/s41571-020-00447-z

Цитирования и источники

Цитирований: 2Использованных источников: 0

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