Статья

A Fully Integrated Wearable Microfluidic Electrochemical Sensor with Ultrasonic Connecting and Hot-Pressing Bonded Multilayer Structure for Sweat Biomarker Analysis

Guodong LiuSchool of Mechanical Engineering, Beijing Institute of Technology, 5 South Zhongguancun Street, Haidian District, Beijing 100081, ChinaXianyang GuanSchool of Mechanical Engineering, Beijing Institute of Technology, 5 South Zhongguancun Street, Haidian District, Beijing 100081, ChinaPingna ZhangBeijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical UniversityQifeng TanSchool of Mechanical Engineering, Jiangsu University of Technology, Zhongwu Avenue, Changzhou 213001, ChinaTianlong LiSchool of Mechanical Engineering, Jiangsu University of Technology, Zhongwu Avenue, Changzhou 213001, ChinaXin JinSchool of Mechanical Engineering, Beijing Institute of Technology, 5 South Zhongguancun Street, Haidian District, Beijing 100081, ChinaHuiqing XuSchool of Mechanical Engineering, Beijing Institute of Technology, 5 South Zhongguancun Street, Haidian District, Beijing 100081, ChinaChaojiang LiSchool of Mechanical Engineering, Beijing Institute of Technology, 5 South Zhongguancun Street, Haidian District, Beijing 100081, ChinaJieliang ZhaoSchool of Mechanical Engineering, Beijing Institute of Technology, 5 South Zhongguancun Street, Haidian District, Beijing 100081, China

2025en

ABI

Аннотация

Wearable microfluidic sweat sensors serve as critical devices for the continuous monitoring of human biomarkers. This research has developed a fully integrated wearable microfluidic electrochemical sensor (FIWMES) for noninvasive, continuous monitoring of glucose, Na+, K+, and Ca2+ in human sweat. To address challenges including sample leakage, structure damage, and difficulties of multiple-biomarker detection, a hybrid bonding process that combines ultrasonic connecting and hot-pressing procedures is presented for structural integration of the FIWMES. The bonding process ensures high interfacial bonding strength (>65 N), excellent sealing performance (no leakage after 200 bends), and precise temperature control (<51 °C) inside the microfluidic chamber. By integrating the dendritic sweat-collecting module, microfluidic chamber, and 3D-arranged sensing units, the FIWMES can achieve efficient sweat capture, sample manipulation, and simultaneous biomarker detection. The glucose sensor exhibits a sensitivity of 6.4 μA/mM with strong anti-interference capability, while the Na+, K+, and Ca2+ sensors display near-Nernstian responses with sensitivities of 65.3, 64.3, and 38.2 mV/decade, respectively. On-body trials confirm the practical wearability and its ability to accurately track dynamic metabolic changes, such as postprandial increases in sweat glucose and electrolyte variation under water deficiency. With its stability and monitoring capabilities, FIWMES offers a technical platform for the effective management of chronic diseases.

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Идентификаторы

DOI: 10.1021/acs.analchem.5c04641

Цитирования и источники

Цитирований: 2Использованных источников: 0

Показатели — AkademScholar