Polydatin alleviated alcoholic liver injury in zebrafish larvae through ameliorating lipid metabolism and oxidative stress
Yu‐Ling LaiSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, ChinaChuying ZhouSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, ChinaPeng HuangFoshan Maternal and Child Health Research Institute, Affiliated Hospital of Southern Medical University, Foshan 528000, ChinaZhaoyang DongSchool of Nursing, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, ChinaChan MoSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, ChinaLingpeng XieSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, ChinaHaiyan LinDepartment of Traditional Chinese Medicine, University of Chinese Academy of Sciences Shenzhen Hospital, Shenzhen, Guangdong, ChinaZhenting ZhouDepartment of Neurology, Huzhou Traditional Chinese Medicine Hospital, Huzhou, Zhejiang, ChinaGuanghui DengSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, ChinaYuan LiuSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, ChinaYuyao ChenSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, ChinaShaohui HuangSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, ChinaZhiyong WuSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, ChinaXuegang SunSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China; The Key Laboratory of Molecular Biology, State Administration of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, ChinaLei GaoSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China; The Key Laboratory of Molecular Biology, State Administration of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China. Electronic address: [email protected]Zhiping LvSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China. Electronic address: [email protected]
2018en
ABI
Аннотация
-specific fluorescent probe. Here, polydatin strongly alleviated hepatic steatosis and decreased the expression levels of alcohol and lipid metabolism-related genes, including CYP2Y3, CYP3A65, HMGCRa, HMGCRb and FASN. Additionally, polydatin inhibited oxidative stress in the liver according to fluorescent probe. Moreover, significantly up-regulated expression of DNA damage-related genes (CHOP, GADD45αa) revealed that polydatin attenuated hepatic apoptosis in larvae. In conclusion, polydatin may improve the liver function of zebrafish with acute alcoholic liver injury through attenuating hepatic fat accumulation, ameliorating lipid and ethanol metabolism and reducing oxidative stress and DNA damage.
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