Biotransformation of natural compounds by fungal microorganisms and their biological activities

Biotransformation of natural compounds involves the modification of bioactive molecules by bacteria and fungi, resulting in derivatives that are more potent, stable, or bioavailable.This process plays a crucial role in drug discovery, particularly in pharmaceuticals and medicinal chemistry.Whole-cell biotransformation utilizes microorganisms to convert natural compounds into bioactive derivatives.Enzymes from these microorganisms catalyze key reactions such as oxidation, hydrolysis, and methylation, enhancing the stability, potency, and bioavailability of the resulting compounds.This review provides a comprehensive summary of 116 modified metabolites produced through microbial transformation by various microorganisms.We explore their chemical structures and pharmacological properties, highlighting their significance.This review aims to support researchers in biotechnology, organic chemistry, medicinal chemistry, and pharmacology by offering valuable insights into these biotransformation products.

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