Current Strategies for Promoting the Large-scale Production ofExosomes
Qing QuDepartment of Tissue Engineering, School of Intelligent Medicine, China Medical University, 77 Puhe Avenue,
Shenbei New District, Shenyang, 110122, ChinaBin FuDepartment of Tissue Engineering, School of Intelligent Medicine, China Medical University, 77 Puhe Avenue,
Shenbei New District, Shenyang, 110122, ChinaYong LongDepartment of Tissue Engineering, School of Intelligent Medicine, China Medical University, 77 Puhe Avenue,
Shenbei New District, Shenyang, 110122, ChinaZiyu LiuDepartment of Tissue Engineering, School of Intelligent Medicine, China Medical University, 77 Puhe Avenue,
Shenbei New District, Shenyang, 110122, ChinaXiaohong TianDepartment of Tissue Engineering, School of Intelligent Medicine, China Medical University, 77 Puhe Avenue,
Shenbei New District, Shenyang, 110122, China
2023en
ABI
Аннотация
Exosomes, as nanoscale biological vesicles, have been shown to have great potential for biomedical applications. However, the low yield of exosomes limits their application. In this review, we focus on methods to increase exosome yield. Two main strategies are used to increase exosome production, one is based on genetic manipulation of the exosome biogenesis and release pathway, and the other is by pretreating parent cells, changing the culture method or adding different components to the medium. By applying these strategies, exosomes can be produced on a large scale to facilitate their practical application in the clinic.
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