Статья

Cancer Stem Cell Metabolism

Fidelia B. AlvinaUniversity of Wisconsin-Madison, Madison, WI, USAArvin M. GouwDivision of Oncology, Departments of Medicine and Pathology, Stanford University School of Medicine, Stanford, CA, USAAnne LeDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University Whiting School of Engineering, Baltimore, MD, USA. [email protected]

2021en

ABI

Аннотация

Cancer stem cells (CSCs), also known as tumorinitiating cells (TICs), are a group of cells found within cancer cells. Like normal stem cells, CSCs can proliferate, engage in self-renewal, and are often implicated in the recurrence of tumors after therapy [1, 2]. The existence of CSCs in various types of cancer has been proven, such as in acute myeloid leukemia (AML) [3], breast [4], pancreatic [5], and lung cancers [6], to name a few. There are two theories regarding the origin of CSCs. First, CSCs may have arisen from normal stem/progenitor cells that experienced changes in their environment or genetic mutations. On the other hand, CSCs may also have originated from differentiated cells that underwent genetic and/or heterotypic modifications [7]. Either way, CSCs reprogram their metabolism in order to support tumorigenesis.

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Идентификаторы

DOI: 10.1007/978-3-030-65768-0_12

Цитирования и источники

Цитирований: 3Использованных источников: 0

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