NASLIY VA ORTTIRILGAN TROMBOTSITOPATIYALARNING MOLEKULYAR-PATOGENETIK MEXANIZMLARI VA KLINIK-DIAGNOSTIK JIHATLARI

Inherited and acquired thrombocytopathies are disorders characterized by abnormal platelet function, which leads to bleeding tendencies despite normal platelet counts. Inherited thrombocytopathies, such as Glanzmann thrombasthenia and Bernard-Soulier syndrome, are caused by genetic mutations affecting platelet membrane glycoproteins or signaling pathways. Acquired thrombocytopathies, on the other hand, result from external factors such as medications, chronic diseases, or autoimmune conditions. Diagnosis relies on clinical evaluation, laboratory tests including platelet aggregation studies, flow cytometry, and genetic analysis in inherited forms. Management depends on the type and severity of the disorder and may include platelet transfusions, desmopressin administration, or targeted therapies. Understanding the mechanisms and differences between inherited and acquired forms is crucial for effective diagnosis and treatment.

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