Обзорная статья

The role of <scp>SF3B1</scp> and <scp>NOTCH1</scp> in the pathogenesis of leukemia

Shiva AbolhasaniImmunology Research Center Tabriz University of Medical Sciences Tabriz IranSeyyed Sina HejazianImmunology Research Center Tabriz University of Medical Sciences Tabriz IranVahid KarpishehImmunology Research Center Tabriz University of Medical Sciences Tabriz IranAtefeh KhodakaramiImmunology Research Center Tabriz University of Medical Sciences Tabriz IranHamed MohammadiNon‐communicable Diseases Research Center Alborz University of Medical Sciences Karaj IranJamshid Gholizadeh NavashenaqNon‐communicable Diseases Research Center Bam University of Medical Sciences Bam IranMohammad Hojjat‐FarsangiBioclinicum, Department of Oncology‐Pathology, Karolinska Institute Stockholm SwedenFarhad Jadidi‐NiaraghDepartment of Immunology, Faculty of Medicine Tabriz University of Medical Sciences Tabriz Iran

2022en

ABI

Аннотация

The discovery of new genes/pathways improves our knowledge of cancer pathogenesis and presents novel potential therapeutic options. For instance, splicing factor 3b subunit 1 (SF3B1) and NOTCH1 genetic alterations have been identified at a high frequency in hematological malignancies, such as leukemia, and may be related to the prognosis of involved patients because they change the nature of malignancies in different ways like mediating therapeutic resistance; therefore, studying these gene/pathways is essential. This review aims to discuss SF3B1 and NOTCH1 roles in the pathogenesis of various types of leukemia and the therapeutic potential of targeting these genes or their mutations to provide a foundation for leukemia treatment.

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Идентификаторы

DOI: 10.1002/iub.2660

Цитирования и источники

Цитирований: 2Использованных источников: 0

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