Novel strategies to overcome tumor immunotherapy resistance using CAR NK cells
Junhui GuoDepartment of Oncology, The Second Affiliated Hospital of Henan University of Traditional Chinese Medicine, Henan Province Hospital of Traditional Chinese Medicine, Zhengzhou, Henan, ChinaAli AfzalInstitute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, ChinaSadia AhmadInstitute of Zoology, University of the Punjab, Lahore, PakistanGhazala SaeedInstitute of Zoology, University of the Punjab, Lahore, PakistanAmna RehmanInstitute of Zoology, University of the Punjab, Lahore, PakistanUmair Ali Khan SaddozaiInstitute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, ChinaLei LiuDepartment of Cardiovascular Surgery, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, ChinaShihao GuoDepartment of Colorectal Surgery, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, ChinaXin‐Ying JiCenter for Molecular Medicine, Faculty of Basic Medical Subjects, Shu-Qing Medical College of Zhengzhou, Zhengzhou, Henan, ChinaMuhammad Babar KhawarApplied Molecular Biology and Biomedicine Lab, Department of Zoology, University of Narowal, Narowal, Pakistan
2025en
ABI
Аннотация
While immunotherapy faces obstacles, the emergence of chimeric antigen receptor (CAR) engineered natural killer (NK) cells is paving new ways and might become a preferred option over CAR T cells very soon. CAR NK introduce diverse cytotoxic mechanisms offering novel strategies to combat tumor immunotherapy resistance. Concurrently, improvements in NK cell homing and gene-edited CAR NK cell therapy offer promising avenues for overcoming challenges in cancer immunotherapy. Our review addresses resistance mechanisms and engineering strategies to enhance CAR NK cell functionality by improving NK cell homing and migration to tumor sites, emphasizing insights from preclinical and clinical studies.
Перевод пока недоступен
Идентификаторы
Цитирования и источники
Цитирований: 2Использованных источников: 0