Обзорная статья

Bioactive Materials for Bone Regeneration: Biomolecules and Delivery Systems

Aleksandra SzwedDepartment of Immunology and Infectious Biology, Faculty of Biology and Environmental Protection, University of Lodz, Lodz 90-136, PolandPrzemysław PłocińskiDepartment of Immunology and Infectious Biology, Faculty of Biology and Environmental Protection, University of Lodz, Lodz 90-136, PolandBarbara Kupikowska‐StobbaBiomaterials Research Group, Lukasiewicz Research Network - Institute of Ceramics and Building Materials, Krakow 31-983, PolandMateusz M. UrbaniakDepartment of Immunology and Infectious Biology, Faculty of Biology and Environmental Protection, University of Lodz, Lodz 90-136, PolandPaulina Rusek‐WalaDepartment of Immunology and Infectious Biology, Faculty of Biology and Environmental Protection, University of Lodz, Lodz 90-136, PolandKonrad SzustakiewiczDepartment of Polymer Engineering and Technology, Faculty of Chemistry, Wroclaw University of Technology, Wroclaw 50-370, PolandPaweł J. PiszkoDepartment of Polymer Engineering and Technology, Faculty of Chemistry, Wroclaw University of Technology, Wroclaw 50-370, PolandAgnieszka KrupaDepartment of Immunology and Infectious Biology, Faculty of Biology and Environmental Protection, University of Lodz, Lodz 90-136, PolandMonika BiernatBiomaterials Research Group, Lukasiewicz Research Network - Institute of Ceramics and Building Materials, Krakow 31-983, PolandMałgorzata GazińskaDepartment of Polymer Engineering and Technology, Faculty of Chemistry, Wroclaw University of Technology, Wroclaw 50-370, PolandMirosław KasprzakBiomaterials Research Group, Lukasiewicz Research Network - Institute of Ceramics and Building Materials, Krakow 31-983, PolandKatarzyna NawrotekFaculty of Process and Environmental Engineering, Lodz University of Technology, Lodz 90-924, PolandNuno P. MiraAssociate Laboratory i4HB-Institute for Health and Bioeconomy at Instituto Superior Técnico, Universidade de Lisboa, Lisboa 1049-001, PortugalKarolina RudnickaDepartment of Immunology and Infectious Biology, Faculty of Biology and Environmental Protection, University of Lodz, Lodz 90-136, Poland

2023en

ABI

Аннотация

Novel tissue regeneration strategies are constantly being developed worldwide. Research on bone regeneration is noteworthy, as many promising new approaches have been documented with novel strategies currently under investigation. Innovative biomaterials that allow the coordinated and well-controlled repair of bone fractures and bone loss are being designed to reduce the need for autologous or allogeneic bone grafts eventually. The current engineering technologies permit the construction of synthetic, complex, biomimetic biomaterials with properties nearly as good as those of natural bone with good biocompatibility. To ensure that all these requirements meet, bioactive molecules are coupled to structural scaffolding constituents to form a final product with the desired physical, chemical, and biological properties. Bioactive molecules that have been used to promote bone regeneration include protein growth factors, peptides, amino acids, hormones, lipids, and flavonoids. Various strategies have been adapted to investigate the coupling of bioactive molecules with scaffolding materials to sustain activity and allow controlled release. The current manuscript is a thorough survey of the strategies that have been exploited for the delivery of biomolecules for bone regeneration purposes, from choosing the bioactive molecule to selecting the optimal strategy to synthesize the scaffold and assessing the advantages and disadvantages of various delivery strategies.

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Идентификаторы

DOI: 10.1021/acsbiomaterials.3c00609

Цитирования и источники

Цитирований: 2Использованных источников: 0

Показатели — AkademScholar