Comparative mechanistic study of green-synthesized silver-zinc oxide (Ag-ZnO) and iron–Zinc oxide (Fe-ZnO) bimetallic nanoparticles in antiglycation, antidiabetic, antioxidant, and anticancer activities

Bimetallic nanoparticles (BNPs) have gained immense attention for their diverse biological applications. This study aimed to biosynthesize and characterize Ag-ZnONPs and Fe-ZnONPs and compare their potential as therapeutic agents. The BNPs were synthesized using Mentha asiatica plant extract and characterized using various techniques such as UV-visible spectroscopy, TEM, EDX spectroscopy, ATR-FTIR spectroscopy, PXRD, DLS, and zeta potential analyses. TEM, EDX, and XRD revealed the structural and morphological properties of crystalline Ag-ZnONPs and Fe-ZnONPs. FTIR analysis investigated the plant phytochemicals responsible for the stabilization and capping of BNPs. Ag-ZnONPs showed higher biocompatibility than Fe-ZnONPs. Fe-ZnONPs exhibited-significantly higher anticancer potential than Ag-ZnONPs as evident by Reactive Oxygen Species/ Nitric Oxide Synthase production, along with cell viability analysis, loss of mitochondrial-membrane potential, enhanced caspase-3 gene-expression, and intensified activity of Caspase-3/7. Collectively, our findings underscore the promising therapeutic-potential of BNPs in cancer treatment and diabetes, setting them as strong candidates for future biomedical applications.

Перевод пока недоступен