Rapid purification of tissue inhibitor of metalloproteinases from human plasma and identification as a γ-serum protein
Tim E. CawstonRheumatology Research Unit, Unit E6, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ,D N NobleRheumatology Research Unit, Unit E6, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ,Gillian MurphyAlan Jay SmithRheumatology Research Unit, Unit E6, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ,Charles L. WoodleyRheumatology Research Unit, Unit E6, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ,B L HazlemanRheumatology Research Unit, Unit E6, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ,
ABI
Аннотация
A rapid method is described for the purification of human tissue inhibitor of metalloproteinases (TIMP) from plasma which involves immuno-affinity chromatography and gel filtration. The purified plasma inhibitor is immunologically identical with the TIMP previously purified from human amniotic fluid, human synovial fluid and human fibroblast culture medium. It is proposed that this inhibitor is identical with the plasma inhibitor previously named 'B1 anticollagenase', although the plasma inhibitor was shown to migrate as a gamma-serum component.
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