Oligonucleotide Derivatives in Organism: Distribution Among Organs, Rates of Release and Degradation
Olga Bazanovaa Institute of Bloorganic Chemistry , 630090 , Novosibirsk , USSRValentin V. Vlassova Institute of Bloorganic Chemistry , 630090 , Novosibirsk , USSRВ. Ф. Зарытоваa Institute of Bloorganic Chemistry , 630090 , Novosibirsk , USSRE. M. Ivanova Institute of Bloorganic Chemistry , 630090 , Novosibirsk , USSRE. A. Kuliginaa Institute of Bloorganic Chemistry , 630090 , Novosibirsk , USSRL. A. Yakubova Institute of Bloorganic Chemistry , 630090 , Novosibirsk , USSRM. Abdukayumovb NPO Rgdiopreparst, Institute of Nuclear Physics , Tashkent , USSRV.N. Karamyshevb NPO Rgdiopreparst, Institute of Nuclear Physics , Tashkent , USSRG. Zonc Applied Blosystems, Inc. , Foster City , CA , 94404 , USA
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Аннотация
Abstract oligonucleotide derivatives were observed partially degraded in all tissues of mice 30 min post-injection. Conoentration in liver and kidney was 100-fold larger than in brain. Phosphorothioate oligos were more resistant than pho-sphodiesters.
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