Glass-Ceramic Scaffolds and Shock Waves Effect on Cells Migration

Glass-ceramic scaffolds for bone grafting have been prepared using the sponge replication method and a highly bioactive silica based glass belonging to the system SiO2-P2O5- CaO-MgO-Na2O-K2O (CEL2). The parameters for the sponge impregnation were optimized in order to obtain a continuous coating of the polymeric skeleton which will lead, after the polymeric phase removal, to a resistant macroporous glass-ceramic template. A complete characterization was carried out on the obtained scaffold in order to assess its morphology and specifically its porosity and the degree of pores interconnection. A human osteoblasts cells line (MG-63) was cultured onto the scaffold and the effect of stimulation with shock waves on the cell ability of colonizing the scaffold was investigated.

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