NEUROSONOGRAPHY AND HEMOSTASIS DATA IN PREMATURE NEWBORNS WITH HYPOXIC-ISCHEMIC ENCEPHALOPATHY

Background Hypoxic-ischemic damage to the brain in preterm newborns is a significant current problem in neonatology. Methods 140 newborns of 28–36 weeks gestation at 820–2650 g have been investigated. All the patients have been devided into groups according to ultrasound and Doppler-metric changes. The 1st group included children with intra- and periventricular 1st, 2nd and 3rd degree bleedings. The 2nd group included patients with 1st, 2nd and 3rd degree hypoxic-ischemic damage of the CNS. The 3rd group included so called *healthy* children. Para-clinical methods included haemostasis condition on the 1st, 3rd, 5th and 7th days of life. Results On the 3rd day of life 5.1% decreases of fibrinogen count in blood serum have been noted. Increase of thrombocites (10.4%) and simultaneous decrease of APTT (7.3%) in the 1st group children in comparison to the control group have been revealed. In the 2nd group the spread and duration of celebral ischemia was accompanied by fibrinogen increase (7.1%), thrombocytes (9.2%) and APTT: 13.7% in comparison to the control group. Conclusion Complex study of the haemostasis system and neurosonography data were associated with different clinical manifistations. Peri- and intraventricular bleedings were accompanied by thrombocyte count decrease and plasma-coagulation increase. Hypoxic-ischemic brain damage was accompanied by thrombocyte count increase and plasma-coagulation haemostasis decrease. So the combination of neurosonography and haemostasis investigation on the 1st–7th days of life is an effective method and significant for diagnostics of celebral pathology in preterm newborns.

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