Direct comparison of GeneXpert MTB/RIF (Cepheid) with probeTEC (Becton-Dickinson) and Taqman MTB (Roche) for detection of TB bacteria
Harald HoffmannIML Red GmbH, Synlab Bayern, Asklepios Fachklinken, WHO Supranationales Referenzlabor für Tuberkulose, GautingSabine Hofmann-ThielIML Red GmbH, Synlab Bayern, Asklepios Fachklinken, WHO Supranationales Referenzlabor für Tuberkulose, GautingLaziz TuraevNational Institute of Tuberculosis, National Reference Laboratory of Tuberculosis, Tashkent, Republic of UzbekistanA EsenalievaNational Reference Laboratory of Tuberculosis, Bishkek, Republic of KyrgyzstanM AbdullaevaK MirazimNational Institute of Tuberculosis, National Reference Laboratory of Tuberculosis, Tashkent, Republic of UzbekistanUladzimir AntonenkaIML Red GmbH, Synlab Bayern, Asklepios Fachklinken, WHO Supranationales Referenzlabor für Tuberkulose, Gauting
ABI
Аннотация
Background: With the GeneXpert MTB/RIF system, Cepheid and FIND have launched an innovative solution of TB diagnostics. It is easy to use, bio-safe, resistant to DNA-contamination, fulfilling many POCT criteria. As to detection of TB bacteria (MTBC) in respiratory specimens, a recent multi-centre-evaluation-study (Böhme et al. 2010) described 98.2% sensitivity in smear positive (ss+) sputa, 72.5% in smear negative (ss-) ones, while specificity reached 99.2%. These values are higher than most ones reported for commercial assays so far.
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