Chemical transformations of N-morpholinylacetic acid hydrazide and steric structure of its derivatives
О. А. НуркеновInstitute of Organic Synthesis and Coal Chemistry of Kazakhstan, ul. Alikhanova 1, Karaganda, 100008, KazakhstanС. Д. ФазыловInstitute of Organic Synthesis and Coal Chemistry of Kazakhstan, ul. Alikhanova 1, Karaganda, 100008, KazakhstanЖ. Б. СатпаеваInstitute of Organic Synthesis and Coal Chemistry of Kazakhstan, ul. Alikhanova 1, Karaganda, 100008, KazakhstanИ. В. КулаковInstitute of Organic Synthesis and Coal Chemistry of Kazakhstan, ul. Alikhanova 1, Karaganda, 100008, KazakhstanК. М. ТурдыбековД. М. ТурдыбековMulti-Profile Humanitarian-Technical University, pr. Bukhar Zhyrau 12, Karaganda, 100000, KazakhstanS. A. TalipovSadykov Institute of Bioorganic Chemistry, Academy of Science of Uzbekistan, Tashkent, UzbekistanБ. Т. ИбрагимовSadykov Institute of Bioorganic Chemistry, Academy of Science of Uzbekistan, Tashkent, Uzbekistan
ABI
Аннотация
The reaction of N-morpholinylacetic acid hydrazide with various isothiocyanates and potassium thiocyanate resulted in the corresponding potentially biologically active thiosemicarbazide derivatives. Potassium N′-(2-morpholin-4-ylacetyl)hydrazinocarbothioate was synthesized and involved into heterocyclization in acidic environment to yield cyclic 5-(morpholinomethyl)-1,3,4-thiadiazole-2-thione. The structure of the synthesized compounds was established by IR, 1H NMR spectroscopy, mass spectrometry, and XRD analysis.
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