Designing the nanobiointerface of fluorescent nanodiamonds: highly selective targeting of glioma cancer cells
Jitka ŠlegerováCharles UniversityMiroslav HájekInstitute of Organic Chemistry and Biochemistry AS CR, v.v.iIvan ŘehořInstitute of Organic Chemistry and Biochemistry AS CR, v.v.iFrantišek SedlákCharles UniversityJan ŠtursaNuclear Physics Institute AS CR, v.v.iMartin HrubýInstitute of Macromolecular Chemistry AS CR, v.v.iPetr CíglerInstitute of Organic Chemistry and Biochemistry AS CR, v.v.i
ABI
Аннотация
Core-shell nanoparticles based on fluorescent nanodiamonds coated with a biocompatible N-(2-hydroxypropyl)methacrylamide copolymer shell were developed for background-free near-infrared imaging of cancer cells. The particles showed excellent colloidal stability in buffers and culture media. After conjugation with a cyclic RGD peptide they selectively targeted integrin αvβ3 receptors on glioblastoma cells with high internalization efficacy.
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