Clinical Efficiency of Bisoprolol in Patients with Coronary Heart Disease Depending on Polymorphous Marker Type of ADRB-1 Gene

At present, in order to influence the indices of the global contractions of the left ventricles in patients with coronary heart disease effectively, genetic characteristics in receptor structure and particularly adrenoreceptors responsible for sympathoadrenal activity should be considered. Patients division depending on the type of polymorphism gives prerequisites for new efficient algorithms for individual selection of medicines, including β-blockers. Taking into consideration the type of polymorphous marker of ADRB- 1 receptor, it is possible to maximize the effect of β-adrenoceptor, thereby to influence effectively the pathogenic mechanism of the disease.

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