FEATURES OF CORONARY ARTERIES LESION AT UNSTABLE ANGINA PATIENTS DEPENDING ON DISTRIBUTION OF APO С-III GENE POLYMORPHISM AND TYPE OF DISLIPIDEMIA

Aim. To study features of coronary arteries atherosclerotic lesions in unstable angina (UA) patients depending on distribution of APO С-III gene polymorphism and type of dislipidemia. Material and methods. There were examined 141 patients of Uzbek nationality with UA class IIB (Braunwald E. et al., 1989). The control group consisted of 50 healthy persons. DNA allocation made from blood by means of a set «Diatom™ DNA Prep 200» under the standard report of firm of the manufacturer (laboratory Isogene Russia). For carrying out PCR of amplification used a set (laboratory SibEnzyme, Russia). The sequence primers was used, according to recommendations Ahmad Reza Bandegi et al, 2011. Results. At the comparative analysis the distribution of S2 alleles SstI polymorphism of gene АРО C-III among the patients with UA in comparison with healthy persons, has been found a more prevalence of S2allelecarriers (HR 2,58, 95% CI 1,2-5,7, Р 230 mg/dl) also prevailed S2 alleles carriers (HR 2,31, 95% CI 1,1-4,7, p <0,05) and occurrence of three-vessel coronary arteries lesion (HR 2,51, 95% CI 1,2-5,1, Р=0,003), whereas in a subgroup with triglycerides level <230 mg/dl have appeared more patients with one-vessellesion (HR 2,52, 95% CI 1,1-5,9, Р<0,05). Conclusion. Presence of three-vessel coronary arteries lesion among unstable angina patientsassociated with S2 alleles SstI polymorphism of gene АРО C-III carriage and hypertriglyceridemia.

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