Role of the Immunological Markers in the Pathogenesis of Symptomatic Epilepsy in Children

The objective of our study was to determine the profile of the spontaneous and mitogen-induced cytokine production in children with symptomatic epilepsy of different etiologies. Materials and Methods: We examined 38 patients (aged between 3 and 18 years) with consequences of strokes (18.4%), neuroinfections (36.8%), neonatal brain injury (28.9%), and brain development anomalies (15.8%). The levels of spontaneous and mitogen-induced production of the main cytokines (IL-2, IL-6, IL-1β, TNFα) were determined by ELISA. Results: We traced the decrease and/or inhibition in the production of the main regulatory cytokines of monocyte-macrophage profile (TNFα, IL-1β, IL-6) and adaptive immunity (IL-2) in children with symptomatic epilepsy; and we also revealed the insufficiency of the innate immunity factors in children, which was expressed in the suppression of the regulatory cytokine production, even with in vitro stimulation.

Ҳали таржима қилинмаган