P57 Pathogenetic value of endothelinin in predicting the clinical course of cardiomyopathy in children

<h3>Relevance</h3> The study of biochemical changes in cardiovascular diseases is one of the urgent problems of pediatric cardiology. Biochemical markers of myocardial damage include cardiospecific proteins - troponin, endothelin and myoglobin, which provide some assistance in specifying an unfavorable cardiomyopathic prognosis. <h3>Purpose of the study</h3> To study the pathogenetic significance of endothelin in predicting the clinical course of cardiomyopathy in children. <h3>Materials and methods</h3> 54 children with diagnoses of dilated and hypertrophic cardiomyopathy were hospitalized in cardioreumatology departments of the Republican Specialized Scientific and Practical Medical Center of Pediatrics in Tashkent and the Republican Children’s Multidisciplinary Medical Center in Nukus. The age of the examined children ranged from 1 year to 17 years and averaged 7.1 ± 0.7 years. Biochemical methods included the determination of endothelin in the serum by immunofluorescence analysis on an IMAXIZ machine using reagents from Hema (Russia). Statistical processing of the data was performed on a personal computer using the software package ‘Statistica 6’. <h3>Results and discussion</h3> Determining plasma concentration of endothelin helps to establish the diagnosis of heart failure in the early stages of the disease. The study of endothelin content depending on the form of cardiomyopathy revealed that the average content of endothelin was unreliable higher in children with hypertrophic cardiomyopathy and corresponded to the upper limit of normal (1.0 ± 0.2 mmol/l, p&gt; 0.05), compared with the rate of children with dilated cardiomyopathy (0, 86 ± 0.1 mmol/l, p&gt; 0.05). However, according to the results of our studies, an increase in the level of endothelin as the progression of the disease was found. Thus, in patients with a disease duration of 5 years, the level of endothelin was 1.3 mmol/l, in patients with a disease duration of 9 years, this figure was 1.7 mmol/l, and in a patient with a disease duration of 15 years - 1.98 mmol/l, which is 2 times the norm. A correlation analysis between the prescription of CMP, the severity of chronic heart failure and the level of endothelin revealed a strong direct correlation (r = + 0.97), which indicates the predictive value of endothelin. From this it follows that determining the plasma concentration of endothelin helps to establish the diagnosis heart failure in the early stages of the disease. <h3>Conclusion</h3> As the disease progresses, an increase in the level of endothelin is a reliable prognostic criterion for the severity of chronic heart failure in children with cardiomyopathy.

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