Comparative analysis of the immune system at often and rarely ill children depending on the stage of disease

The article is devoted to the study of the immune system (IS) and cytokine status in frequently ill children (FIC) in the acute phase and remission in comparison with rarely ill with children (RIC). The immune status in these children not infrequently formed were transiently response by Th2-type by hyper production of IL-4 and IL-1ß, stimulating high production of IgE by B lymphocytes IgA against decrease synthesis. The smallest number of T-suppressor cells defined in the acute stage at FIC, but fluctuations are unreliable, that still caused significant reduction in the immune regulatory index in the group. In the group of FIC in remission as a decline of the index, but compared to the RIC data unreliable. In terms of lymphoid tissue hyperplasia and concomitant chronic exudative-proliferative inflammatory viral infection begins to exhibit the properties of the trigger, inducing infectious-dependent immunopatho logical condition, as well as autoimmune reactions, often manifested by at FIC [1–3]. In other words, the spread of inflammation to the lymphoid tissue of the upper respiratory tract is associated with severe proliferative IgA, indicating mobilization of reserve capacity of local immunity in chronic inflammation.

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