Phenotypic factors as predictors of thrombotic conditionsin patients with chronic obstructive disease
Аннотация
<b>Purpose:</b> To determine the factors that have influence on the changes of hemostasis and which are significant in the development of thrombosis among patients with COPD (n=90). <b>Results:</b> As a result of evaluating the "weight significance" of phenotypic and clinical-laboratory factors, determinants of high prognostic significance that cause an increased risk of developing hypercoagulation states are identified, and the relative risk (RR) is calculated, including - female gender (RR: 1.42(95% Cl: 1.05, 1.79)), age over 60 years (RR: 1.74(95% Cl: 1.22, 2.26)), smoking with a smoker9s index of more than 50 pack/years (RR: 3.13(95% Cl: 2.03, 4.23)), overweight more than 25 kg/m2 (RR: 3.0(95% Cl: 1.7, 4.3)), presence of concomitant diseases–hypertension (RR: 2.22(95% Cl: 1.3, 3.14)), and comorbidity with ischemic heart disease (RR: 1.44(95% Cl: 1.3, 1.58)), clinical IV degree severity of COPD (RR: 1.9(95% Cl: 1.3, 2.58)), bronchitic type of COPD (RR: 1.42(95% Cl: 1.3, 1.58)), prevalence of sympathetic type of regulation of the autonomic nervous system (RR: 1.8(95% Cl: 1.34, 2.28)), increase in inflammation indexes: positive C-reactive protein (RR: 1.29(95% Cl: 1.34, 2.28)), positive rheumofactor (RR: 1.67(95% Cl: 1.24, 2.1)) and increased hemogram parameters: hemoglobin more than 130 g/l (RR: 1.3(95% Cl: 0.91, 1.7)). <b>Conclusion:</b> The determination of the “weight significance” of phenotypic factors, the allocation of highly significant risk parameters for thrombogenic disorders from the totality of all components of the individual allow us to calculate an individualized risk for each patient and determine the differentiated tactics of its management, taking into account the degree of risk.