Prevention of urethrocutaneous fistulas after urethroplasty in patients with glandular and midshaft hypospadias

AIM: To compare the results of treatment of postoperative complications in children with hypospadias. MATERIALS AND METHODS: A total of 123 patients aged 6 months to 16 years were included in the study. An evaluation of the level of reactive oxygen species (ROS) and the state of the antiperoxide system in the eluate was carried out. RESULTS: In the tissues of patients with glandular and midshaft hypospadias after urethroplasty the generation of ROS was enhanced. The products of their interaction with lipid and protein macromolecules can result in the formation of urethrocutaneous fistulas. The use of urethral catheter which allowed to obstruct and rinse the neourethra by a water-soluble antioxidant solution had a good effect on the tissue regeneration and significantly reduced the frequency of urethrocutaneous fistulas. CONCLUSIONS: The proposed method of rinsing the neourethra after urethroplasty in patients with glandular and midshaft hypospadias with a water-soluble antioxidant dibunol allowed to reduce the generation of ROS in the eluate, which resulted in a decrease in the content of SMDA in the eluate by 1.88, an increase in APA by 11.1 and to decrease the frequency of urethrocutaneous fistulas by 2.6 times due to an increase in local regeneration.

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