Мақола

INFLUENCE OF QUERCETIN AND DIHYDROQUERCETIN ON SOME FUNCTIONAL PARAMETERS OF RAT LIVER MITOCHONDRIA

Ulugbek GayibovSabina GayibovaInstitute of Biophysics and Biochemistry under National University of Uzbekistan, Universitet street, Tashkent, UzbekistanMamurjon Komiljonovich PozilovNational University of Uzbekistan named after M.Ulugbek, Universitet street, Tashkent, UzbekistanFeruza Sh. TuxtaevaNational University of Uzbekistan named after M.Ulugbek, Universitet street, Tashkent, UzbekistanUmida R. YusupovaNational University of Uzbekistan named after M.Ulugbek, Universitet street, Tashkent, UzbekistanGulchehra M.-K. DjabbarovaNational University of Uzbekistan named after M.Ulugbek, Universitet street, Tashkent, UzbekistanZulayho A. MamatovaInstitute of Biophysics and Biochemistry under National University of Uzbekistan, Universitet street, Tashkent, UzbekistanNurali ErgashevInstitute of Bioorganic Chemistry named after acad. A.S. Sadykov, Academy of Sciences of Uzbekistan, 83, Mirzo Ulugbek street, 100125, Tashkent, UzbekistanTakhir Aripov

Journal of Microbiology Biotechnology and Food Sciencesjournal2021en

ABI

Аннотация

Flavonoids are proved to be prominent plant-derived compounds generally found in fruit- and vegetable- rich diets with free radicals quenching ability. Quercetin, a member of flavonoids subclass – flavonols, has gained major attention due to its overwhelming potential. Quercetin was demonstrated to preserve diverse degenerative diseases by inhibiting lipid peroxidation. In the present paper, we deal with two polyphenolic compounds’ – quercetin and dihydroquercetin – influence on functional parameters of mitochondria. Thus, the fore mentioned flavonols showed the mitochondrial permeability transition pore (mPTP) inhibition and ATP-sensitive potassium channel activation capacities as well as strong antioxidаnt/antiradiсal activity. Improving functional parameters of mitochondria by both quercetin and dihydroquercetin formed a basic idea of the hypothesis that the studied flavonols may provide antihypoxic defense.

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Мавзулар

Flavonoids in Medical Research Medicinal Plants and Bioactive Compounds Phytochemical and Pharmacological Studies

Идентификаторлар

DOI: 10.15414/jmbfs.2924

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