Мақола

ANALYSIS OF THE ROLE OF THE C807T POLYMORPHISM OF THE ITGA2 GENE WITH THE DEVELOPMENT OF VASCULAR THROMBOSES OF DIFFERENT LOCALIZATIONS.

1Musashaykhov U.Kh.,1- Andijan State Medical Institute2Karimov Kh.Ya.,2- Republican Specialized Scientific and Practical Medical Center for Hematology of the Ministry of Health of the Republic of Uzbekistan (RSNPMCG of the Ministry of Health of the Republic of Uzbekistan)1Musashaykhov Kh.T.,1- Andijan State Medical Institute2Boboev K.T.2- Republican Specialized Scientific and Practical Medical Center for Hematology of the Ministry of Health of the Republic of Uzbekistan (RSNPMCG of the Ministry of Health of the Republic of Uzbekistan)

Zenodo (CERN European Organization for Nuclear Research)repository2021en

ABI

Аннотация

Abstract. The analysis of the genetic factor of the risk of developing vascular thrombosis of various localizations was carried out in 107 patients by studying the frequency of distribution of alleles and genotypes of the C807T polymorphism in the integrin alpha-2 (ITGA2) gene. In both groups, the actual distribution of C807T polymorphism genotypes corresponded to those expected at the Hardy-Weinberg equilibrium (p<0.05). A significant relationship was established between the risk of developing vascular thrombosis of various localization and the distribution of predisposing/protective variants of the C807T polymorphism genotypes in the ITGA2 gene. These data allow us to propose testing of this locus to predict the risk of thrombogenic complications in vascular thrombosis of various localizations (such as DVT, IS and MI).

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Мавзулар

Hermeneutics and Narrative Identity Aging, Elder Care, and Social Issues Health, Medicine and Society

Идентификаторлар

DOI: 10.5281/zenodo.5161722

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